Is autism an autoimmune disease?

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the first 3 years of life and persists into adulthood. There are numerous hypotheses regarding the etiology and pathology of ASD, including a suggested role for immune dysfunction. However, to date, the evidence for involvement of the immune system in autism has been inconclusive. While immune system abnormalities have been reported in children with autistic disorder, there is little consensus regarding the nature of these differences which include both enhanced autoimmunity and reduced immune function. In this review, we discuss current findings with respect to immune function and the spectrum of autoimmune phenomena described in children with ASD.

Original languageEnglish (US)
Pages (from-to)557-562
Number of pages6
JournalAutoimmunity Reviews
Volume3
Issue number7-8 SPEC.ISS.
DOIs
StatePublished - Nov 2004

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Autistic Disorder
Autoimmune Diseases
Immune System
Stereotyped Behavior
Interpersonal Relations
Autoimmunity
Consensus
Communication
Pathology
Autism Spectrum Disorder

Keywords

  • Autism
  • Autoimmune
  • Neurodevelopment

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Is autism an autoimmune disease? / Ashwood, Paul; Van de Water, Judith A.

In: Autoimmunity Reviews, Vol. 3, No. 7-8 SPEC.ISS., 11.2004, p. 557-562.

Research output: Contribution to journalArticle

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