Abstract
Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the first 3 years of life and persists into adulthood. There are numerous hypotheses regarding the etiology and pathology of ASD, including a suggested role for immune dysfunction. However, to date, the evidence for involvement of the immune system in autism has been inconclusive. While immune system abnormalities have been reported in children with autistic disorder, there is little consensus regarding the nature of these differences which include both enhanced autoimmunity and reduced immune function. In this review, we discuss current findings with respect to immune function and the spectrum of autoimmune phenomena described in children with ASD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 557-562 |
| Number of pages | 6 |
| Journal | Autoimmunity Reviews |
| Volume | 3 |
| Issue number | 7-8 SPEC.ISS. |
| DOIs | |
| State | Published - Nov 2004 |
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Keywords
- Autism
- Autoimmune
- Neurodevelopment
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Is autism an autoimmune disease? / Ashwood, Paul; Van de Water, Judith A.
In: Autoimmunity Reviews, Vol. 3, No. 7-8 SPEC.ISS., 11.2004, p. 557-562.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is autism an autoimmune disease?
AU - Ashwood, Paul
AU - Van de Water, Judith A
PY - 2004/11
Y1 - 2004/11
N2 - Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the first 3 years of life and persists into adulthood. There are numerous hypotheses regarding the etiology and pathology of ASD, including a suggested role for immune dysfunction. However, to date, the evidence for involvement of the immune system in autism has been inconclusive. While immune system abnormalities have been reported in children with autistic disorder, there is little consensus regarding the nature of these differences which include both enhanced autoimmunity and reduced immune function. In this review, we discuss current findings with respect to immune function and the spectrum of autoimmune phenomena described in children with ASD.
AB - Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the first 3 years of life and persists into adulthood. There are numerous hypotheses regarding the etiology and pathology of ASD, including a suggested role for immune dysfunction. However, to date, the evidence for involvement of the immune system in autism has been inconclusive. While immune system abnormalities have been reported in children with autistic disorder, there is little consensus regarding the nature of these differences which include both enhanced autoimmunity and reduced immune function. In this review, we discuss current findings with respect to immune function and the spectrum of autoimmune phenomena described in children with ASD.
KW - Autism
KW - Autoimmune
KW - Neurodevelopment
UR - http://www.scopus.com/inward/record.url?scp=8844277748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8844277748&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2004.07.036
DO - 10.1016/j.autrev.2004.07.036
M3 - Article
C2 - 15546805
AN - SCOPUS:8844277748
VL - 3
SP - 557
EP - 562
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 7-8 SPEC.ISS.
ER -