Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age

Torbjörn Lind, Rosadi Seswandhana, Lars Åke Persson, Bo Lönnerdal

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: General iron supplementation to prevent iron deficiency in infants who are iron sufficient when starting supplementation may adversely affect their health. Objective: A secondary analysis to explore the effect of iron supplementation on iron-replete (IR; Hb ≥113 g/L and S-ferritin ≥33 μg/L) or non-iron-replete 6-month-old Indonesian infants participating in a large, randomized trial on iron and zinc supplementation. Results: Among the iron-supplemented IR (Fe-IR, n = 80) infants S-ferritin was, compared to non-iron-supplemented (NS) IR infants (NS-IR, n = 74), significantly higher (47.5 vs. 20.7 μg/L, p = 0.04), and S-zinc significantly lower (9.7 vs. 10.5 μmol/L, p = 0.04). Haemoglobin concentration (Hb) did not differ between the Fe-IR and NS-IR groups. Change in weight-for-age z-score (WAZ) from 6 to 12 months and mean WAZ at 12 months was lower in the Fe-IR group compared to the NS-IR group (-1.45 vs. -1.03, p < 0.001 and -1.97 vs. -1.60, p < 0.001, respectively). There was no difference in morbidity between groups. Iron supplementation of non-iron-replete infants increased Hb and S-ferritin, but did not affect S-zinc or anthropometrical indices. Conclusion: In our study, iron supplementation of IR infants affected WAZ adversely, whereas iron supplementation to non-iron-replete infants did not affect growth. These results support a cautious approach to iron supplementation of IR infants.

Original languageEnglish (US)
Pages (from-to)770-775
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume97
Issue number6
DOIs
StatePublished - Jun 2008

Fingerprint

Iron
Weights and Measures
Zinc
Ferritins
Apoferritins
Hemoglobins
Morbidity
Health
Growth

Keywords

  • Growth
  • Infant
  • Iron replete
  • Iron supplementation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age. / Lind, Torbjörn; Seswandhana, Rosadi; Persson, Lars Åke; Lönnerdal, Bo.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 97, No. 6, 06.2008, p. 770-775.

Research output: Contribution to journalArticle

Lind, Torbjörn ; Seswandhana, Rosadi ; Persson, Lars Åke ; Lönnerdal, Bo. / Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age. In: Acta Paediatrica, International Journal of Paediatrics. 2008 ; Vol. 97, No. 6. pp. 770-775.
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AB - Background: General iron supplementation to prevent iron deficiency in infants who are iron sufficient when starting supplementation may adversely affect their health. Objective: A secondary analysis to explore the effect of iron supplementation on iron-replete (IR; Hb ≥113 g/L and S-ferritin ≥33 μg/L) or non-iron-replete 6-month-old Indonesian infants participating in a large, randomized trial on iron and zinc supplementation. Results: Among the iron-supplemented IR (Fe-IR, n = 80) infants S-ferritin was, compared to non-iron-supplemented (NS) IR infants (NS-IR, n = 74), significantly higher (47.5 vs. 20.7 μg/L, p = 0.04), and S-zinc significantly lower (9.7 vs. 10.5 μmol/L, p = 0.04). Haemoglobin concentration (Hb) did not differ between the Fe-IR and NS-IR groups. Change in weight-for-age z-score (WAZ) from 6 to 12 months and mean WAZ at 12 months was lower in the Fe-IR group compared to the NS-IR group (-1.45 vs. -1.03, p < 0.001 and -1.97 vs. -1.60, p < 0.001, respectively). There was no difference in morbidity between groups. Iron supplementation of non-iron-replete infants increased Hb and S-ferritin, but did not affect S-zinc or anthropometrical indices. Conclusion: In our study, iron supplementation of IR infants affected WAZ adversely, whereas iron supplementation to non-iron-replete infants did not affect growth. These results support a cautious approach to iron supplementation of IR infants.

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