Abstract
Purpose: The aim was to demonstrate that intravenous superparamagnetic iron oxide contrast agents improve the delineation of the portal venous system. Material and methods: The portal venous system of 8 minipigs was demonstrated by a FLASH 2-D MRA-sequence. Scans were acquired before and after intravenous administration of 10 and 20 μmol/kg of a superparamagnetic iron oxide contrast agent (SHU 555 A). Signal intensities were measured in the portal vein and hepatic parenchym and contrast-to-noise ratios were calculated. Results: Following a cumulative dose of 10 μmol iron oxide, hepatic parenchymal signal intensity decreased to 67 ± 6%, following 20 μmol to 29 ± 4%, and following 40 μmol to 13 ± 2% of control (p < 0.0001). These effects improved the contrast-to-noise ratio of the portal vein (469 ± 114%, 858 ± 243%, and 957 ± 272% of control in the left portal vein main branch, p = 0.02). Conclusion: A decrease in hepatic parenchymal signal due to a magnetic susceptibility effect accounts for an improvement of portal venous conspicuity following intravenous administration of iron oxide contrast medium.
Translated title of the contribution | Iron oxide contrast media improve MR-imaging of the portal venous system - An experimental study |
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Original language | German |
Pages (from-to) | 153-158 |
Number of pages | 6 |
Journal | RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren |
Volume | 166 |
Issue number | 2 |
State | Published - Feb 1997 |
Externally published | Yes |
Keywords
- contrast agents
- hepatic disease
- magnetic resonance angiography
- magnetic resonance imaging
- portal vein
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology