Abstract
Aims - To prospectively evaluate the iron nutritional status of preterm infants fed either a term (0.5 mg/dl iron) or preterm (0.9 mg/dl) formulas fortified with iron after hospital discharge. Methods - Healthy low birthweight preterm infants were randomly assigned into three groups at the time of hospital discharge. Group A were fed an iron fortified preterm formula (0.9 mg/dl iron) until 6 months corrected age; group B, a fortified term formula (0.5 mg/l iron) until 6 months corrected age group C, the preterm formula between hospital discharge and term, then the term formula until 6 months corrected age. Results - Seventy eight infants were followed up to 6 months corrected age. Iron intake from formula differed significantly between the groups (A, 1.17 mg/kg/day (SD 0.32) > C, 0.86 mg/kg/day (SD 0.40) = B, 0.81 mg/kg/day (SD 0.23); p < 0.0001). Haemoglobin concentrations were similar to those of iron sufficient preterm infants of the same postnatal age, and term infants of the same postmenstrual age (after 3 months of age). There were no significant differences in haemoglobin concentration (p = 0.391), plasma ferritin (A vs B, p = 0.322), or in the incidence of iron deficiency (A vs B, p = 0.534). Conclusions - Iron fortified formulas containing between 0.5 and 0.9 mg/dl iron seem to meet the iron nutritional needs of preterm infants after hospital discharge.
| Original language | English (US) |
|---|---|
| Journal | Archives of Disease in Childhood: Fetal and Neonatal Edition |
| Volume | 81 |
| Issue number | 1 |
| State | Published - Jul 1999 |
| Externally published | Yes |
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Keywords
- Anaemia
- Infant formula
- Iron deficiency
- Preterm infants
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Iron nutritional status in preterm infants fed formulas fortified with iron. / Griffin, Ian J.; Cooke, Richard J.; Reid, Michael M.; McCormick, Kenneth P B; Smith, Jacqui S.; Griffin, I. J.
In: Archives of Disease in Childhood: Fetal and Neonatal Edition, Vol. 81, No. 1, 07.1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Iron nutritional status in preterm infants fed formulas fortified with iron
AU - Griffin, Ian J.
AU - Cooke, Richard J.
AU - Reid, Michael M.
AU - McCormick, Kenneth P B
AU - Smith, Jacqui S.
AU - Griffin, I. J.
PY - 1999/7
Y1 - 1999/7
N2 - Aims - To prospectively evaluate the iron nutritional status of preterm infants fed either a term (0.5 mg/dl iron) or preterm (0.9 mg/dl) formulas fortified with iron after hospital discharge. Methods - Healthy low birthweight preterm infants were randomly assigned into three groups at the time of hospital discharge. Group A were fed an iron fortified preterm formula (0.9 mg/dl iron) until 6 months corrected age; group B, a fortified term formula (0.5 mg/l iron) until 6 months corrected age group C, the preterm formula between hospital discharge and term, then the term formula until 6 months corrected age. Results - Seventy eight infants were followed up to 6 months corrected age. Iron intake from formula differed significantly between the groups (A, 1.17 mg/kg/day (SD 0.32) > C, 0.86 mg/kg/day (SD 0.40) = B, 0.81 mg/kg/day (SD 0.23); p < 0.0001). Haemoglobin concentrations were similar to those of iron sufficient preterm infants of the same postnatal age, and term infants of the same postmenstrual age (after 3 months of age). There were no significant differences in haemoglobin concentration (p = 0.391), plasma ferritin (A vs B, p = 0.322), or in the incidence of iron deficiency (A vs B, p = 0.534). Conclusions - Iron fortified formulas containing between 0.5 and 0.9 mg/dl iron seem to meet the iron nutritional needs of preterm infants after hospital discharge.
AB - Aims - To prospectively evaluate the iron nutritional status of preterm infants fed either a term (0.5 mg/dl iron) or preterm (0.9 mg/dl) formulas fortified with iron after hospital discharge. Methods - Healthy low birthweight preterm infants were randomly assigned into three groups at the time of hospital discharge. Group A were fed an iron fortified preterm formula (0.9 mg/dl iron) until 6 months corrected age; group B, a fortified term formula (0.5 mg/l iron) until 6 months corrected age group C, the preterm formula between hospital discharge and term, then the term formula until 6 months corrected age. Results - Seventy eight infants were followed up to 6 months corrected age. Iron intake from formula differed significantly between the groups (A, 1.17 mg/kg/day (SD 0.32) > C, 0.86 mg/kg/day (SD 0.40) = B, 0.81 mg/kg/day (SD 0.23); p < 0.0001). Haemoglobin concentrations were similar to those of iron sufficient preterm infants of the same postnatal age, and term infants of the same postmenstrual age (after 3 months of age). There were no significant differences in haemoglobin concentration (p = 0.391), plasma ferritin (A vs B, p = 0.322), or in the incidence of iron deficiency (A vs B, p = 0.534). Conclusions - Iron fortified formulas containing between 0.5 and 0.9 mg/dl iron seem to meet the iron nutritional needs of preterm infants after hospital discharge.
KW - Anaemia
KW - Infant formula
KW - Iron deficiency
KW - Preterm infants
UR - http://www.scopus.com/inward/record.url?scp=0032984044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032984044&partnerID=8YFLogxK
M3 - Article
C2 - 10375362
AN - SCOPUS:0032984044
VL - 81
JO - Archives of Disease in Childhood: Fetal and Neonatal Edition
JF - Archives of Disease in Childhood: Fetal and Neonatal Edition
SN - 1359-2998
IS - 1
ER -