Iron nutritional status in preterm infants fed formulas fortified with iron

Ian J. Griffin, Richard J. Cooke, Michael M. Reid, Kenneth P B McCormick, Jacqui S. Smith, I. J. Griffin

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Aims - To prospectively evaluate the iron nutritional status of preterm infants fed either a term (0.5 mg/dl iron) or preterm (0.9 mg/dl) formulas fortified with iron after hospital discharge. Methods - Healthy low birthweight preterm infants were randomly assigned into three groups at the time of hospital discharge. Group A were fed an iron fortified preterm formula (0.9 mg/dl iron) until 6 months corrected age; group B, a fortified term formula (0.5 mg/l iron) until 6 months corrected age group C, the preterm formula between hospital discharge and term, then the term formula until 6 months corrected age. Results - Seventy eight infants were followed up to 6 months corrected age. Iron intake from formula differed significantly between the groups (A, 1.17 mg/kg/day (SD 0.32) > C, 0.86 mg/kg/day (SD 0.40) = B, 0.81 mg/kg/day (SD 0.23); p < 0.0001). Haemoglobin concentrations were similar to those of iron sufficient preterm infants of the same postnatal age, and term infants of the same postmenstrual age (after 3 months of age). There were no significant differences in haemoglobin concentration (p = 0.391), plasma ferritin (A vs B, p = 0.322), or in the incidence of iron deficiency (A vs B, p = 0.534). Conclusions - Iron fortified formulas containing between 0.5 and 0.9 mg/dl iron seem to meet the iron nutritional needs of preterm infants after hospital discharge.

Original languageEnglish (US)
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Volume81
Issue number1
StatePublished - Jul 1999
Externally publishedYes

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Infant Formula
Nutritional Status
Premature Infants
Iron
Hemoglobins
Ferritins
Age Groups

Keywords

  • Anaemia
  • Infant formula
  • Iron deficiency
  • Preterm infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Griffin, I. J., Cooke, R. J., Reid, M. M., McCormick, K. P. B., Smith, J. S., & Griffin, I. J. (1999). Iron nutritional status in preterm infants fed formulas fortified with iron. Archives of Disease in Childhood: Fetal and Neonatal Edition, 81(1).

Iron nutritional status in preterm infants fed formulas fortified with iron. / Griffin, Ian J.; Cooke, Richard J.; Reid, Michael M.; McCormick, Kenneth P B; Smith, Jacqui S.; Griffin, I. J.

In: Archives of Disease in Childhood: Fetal and Neonatal Edition, Vol. 81, No. 1, 07.1999.

Research output: Contribution to journalArticle

Griffin, IJ, Cooke, RJ, Reid, MM, McCormick, KPB, Smith, JS & Griffin, IJ 1999, 'Iron nutritional status in preterm infants fed formulas fortified with iron', Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 81, no. 1.
Griffin, Ian J. ; Cooke, Richard J. ; Reid, Michael M. ; McCormick, Kenneth P B ; Smith, Jacqui S. ; Griffin, I. J. / Iron nutritional status in preterm infants fed formulas fortified with iron. In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 1999 ; Vol. 81, No. 1.
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N2 - Aims - To prospectively evaluate the iron nutritional status of preterm infants fed either a term (0.5 mg/dl iron) or preterm (0.9 mg/dl) formulas fortified with iron after hospital discharge. Methods - Healthy low birthweight preterm infants were randomly assigned into three groups at the time of hospital discharge. Group A were fed an iron fortified preterm formula (0.9 mg/dl iron) until 6 months corrected age; group B, a fortified term formula (0.5 mg/l iron) until 6 months corrected age group C, the preterm formula between hospital discharge and term, then the term formula until 6 months corrected age. Results - Seventy eight infants were followed up to 6 months corrected age. Iron intake from formula differed significantly between the groups (A, 1.17 mg/kg/day (SD 0.32) > C, 0.86 mg/kg/day (SD 0.40) = B, 0.81 mg/kg/day (SD 0.23); p < 0.0001). Haemoglobin concentrations were similar to those of iron sufficient preterm infants of the same postnatal age, and term infants of the same postmenstrual age (after 3 months of age). There were no significant differences in haemoglobin concentration (p = 0.391), plasma ferritin (A vs B, p = 0.322), or in the incidence of iron deficiency (A vs B, p = 0.534). Conclusions - Iron fortified formulas containing between 0.5 and 0.9 mg/dl iron seem to meet the iron nutritional needs of preterm infants after hospital discharge.

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