Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis

Asli Mete, H. G. Hendriks, P. H M Klaren, G. M. Dorrestein, J. E. Van Dijk, J. J M Marx

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Iron overload is a very frequent finding in several animal species and a genetic predisposition is suggested. In one of the most commonly reported species with susceptibility for iron overload (mynah bird), it was recently shown that the cause of this pathophysiology is high uptake and retention of dietary iron. Here we compare susceptible (mynahs) with non-susceptible avian species (chickens) by evaluating iron uptake at the intestinal absorptive cell level. Enterocytes from mynahs and chickens were isolated and uptake of Fe(II) and Fe(III) was studied in vitro. It was found that Fe(III) uptake is much lower than Fe(II) uptake for both species. Although liver iron, present only in hepatocytes, was at least 10-fold higher in mynahs than chickens, enterocyte Fe(II) uptake was considerably higher in mynahs. Fe(II) uptake showed saturation at the studied concentrations in both species. Kinetic studies revealed a three-fold increase in Vmax for mynahs. Calculated values for the uptake kinetics of the probable membrane transporter suggest that mynah bird enterocytes have a significantly higher limiting uptake rate, due to the possible increase in the number of transporters when compared with chicken enterocytes. The susceptibility of this species is due to intestinal iron uptake despite hepatic iron accumulation, implicating a 'mis-sensing' of body iron similarly to human hereditary haemochromatosis.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalAvian Pathology
Volume32
Issue number6
DOIs
StatePublished - Dec 2003
Externally publishedYes

Fingerprint

hemochromatosis
Starlings
Hemochromatosis
Birds
Iron
iron
uptake mechanisms
Enterocytes
metabolism
birds
Chickens
enterocytes
Iron Overload
chickens
iron overload
Dietary Iron
transporters
Membrane Transport Proteins
Liver
Genetic Predisposition to Disease

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Mete, A., Hendriks, H. G., Klaren, P. H. M., Dorrestein, G. M., Van Dijk, J. E., & Marx, J. J. M. (2003). Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis. Avian Pathology, 32(6), 625-632. https://doi.org/10.1080/03079450310001610659

Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis. / Mete, Asli; Hendriks, H. G.; Klaren, P. H M; Dorrestein, G. M.; Van Dijk, J. E.; Marx, J. J M.

In: Avian Pathology, Vol. 32, No. 6, 12.2003, p. 625-632.

Research output: Contribution to journalArticle

Mete, A, Hendriks, HG, Klaren, PHM, Dorrestein, GM, Van Dijk, JE & Marx, JJM 2003, 'Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis', Avian Pathology, vol. 32, no. 6, pp. 625-632. https://doi.org/10.1080/03079450310001610659
Mete, Asli ; Hendriks, H. G. ; Klaren, P. H M ; Dorrestein, G. M. ; Van Dijk, J. E. ; Marx, J. J M. / Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis. In: Avian Pathology. 2003 ; Vol. 32, No. 6. pp. 625-632.
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