Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants

Penni D. Hicks, Nelly Zavaleta, Zhensheng Chen, Steven A. Abrams, Bo Lönnerdal

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Iron absorption in adults is regulated by homeostatic mechanisms that decrease absorption when iron status is high. There are few data, however, regarding the existence of a similar homeostatic regulation in infants. We studied 2 groups of human milk-fed infants using 57Fe (given as ferrous sulfate without any milk) and 58Fe (given at the time of a breast-milk feeding) stable isotopes to determine whether healthy infants at risk for iron deficiency would regulate their iron absorption based on their iron status. We studied 20 Peruvian infants at 5-6 mo of age and 18 infants at 9-10 mo of age. We found no effect of infant hemoglobin concentration on iron absorption with 5-6 mo-old infants absorbing 19.2 ± 2.1% and 9- to 10-mo-old infants absorbing 25.8 ± 2.6% of the 57Fe dose. For 58Fe, 5- to 6-mo-old infants absorbed 42.665.0% and 9 to 10-mo-old infants absorbed 51.9 ± 10.3%. Following log transformation, iron absorption from 57Fe (r = -0.61, P = < 0.001) and 58Fe (r=-0.61, P=<0.001) were inversely correlated to serum ferritin (S-Ft). For both the 57Fe and 58Fe doses, infants with S-Ft <12 mg/L (n=11) had significantly higher iron absorption than those with S-Ft.12 mg/L. We concluded that iron absorption in infants is related to iron status as assessed by serum ferritin but not hemoglobin concentration. Infants with low iron status upregulate iron absorption from breast milk at both 5-6 and 9-10 mo of age.

Original languageEnglish (US)
Pages (from-to)2435-2438
Number of pages4
JournalJournal of Nutrition
Volume136
Issue number9
StatePublished - 2006

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iron absorption
Iron-Deficiency Anemias
anemia
breasts
Breast
Up-Regulation
Iron
iron
ferritin
breast milk
Human Milk
Ferritins
hemoglobin
ferrous sulfate
infants
dosage
Hemoglobins
Serum
stable isotopes
milk

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Hicks, P. D., Zavaleta, N., Chen, Z., Abrams, S. A., & Lönnerdal, B. (2006). Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. Journal of Nutrition, 136(9), 2435-2438.

Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. / Hicks, Penni D.; Zavaleta, Nelly; Chen, Zhensheng; Abrams, Steven A.; Lönnerdal, Bo.

In: Journal of Nutrition, Vol. 136, No. 9, 2006, p. 2435-2438.

Research output: Contribution to journalArticle

Hicks, PD, Zavaleta, N, Chen, Z, Abrams, SA & Lönnerdal, B 2006, 'Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants', Journal of Nutrition, vol. 136, no. 9, pp. 2435-2438.
Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lönnerdal B. Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. Journal of Nutrition. 2006;136(9):2435-2438.
Hicks, Penni D. ; Zavaleta, Nelly ; Chen, Zhensheng ; Abrams, Steven A. ; Lönnerdal, Bo. / Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. In: Journal of Nutrition. 2006 ; Vol. 136, No. 9. pp. 2435-2438.
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