Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium

Luciana F. Costa, Juliana P S Mol, Ana Patricia C Silva, Auricélio A. Macêdo, Teane M A Silva, Geraldo E S Alves, Sebastian Winter, Maria G. Winter, Eric M. Velazquez, Mariana X. Byndloss, Andreas J Baumler, Renee M Tsolis, Tatiane A. Paixão, Renato L. Santos

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Salmonella enterica serotype Typhimurium is able to expand in the lumen of the inflamed intestine through mechanisms that have not been fully resolved. Here we utilized streptomycin-pretreated mice and dextran sodium sulfate (DSS)-treated mice to investigate how pathways for S. Typhimurium iron acquisition contribute to pathogen expansion in the inflamed intestine. Competitive infection with an iron uptake-proficient S. Typhimurium strain and mutant strains lacking tonB feoB, feoB, tonB or iroN in streptomycin pretreated mice demonstrated that ferric iron uptake requiring IroN and TonB conferred a fitness advantage during growth in the inflamed intestine. However, the fitness advantage conferred by ferrous iron uptake mechanisms was independent of inflammation and was only apparent in models where the normal microbiota composition had been disrupted by antibiotic treatment.

Original languageEnglish (US)
Pages (from-to)604-610
Number of pages7
JournalInternational Journal of Medical Microbiology
Volume306
Issue number8
DOIs
StatePublished - Dec 1 2016

Keywords

  • Animal models
  • Fe
  • Fe
  • Inflammation
  • Salmonella

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Costa, L. F., Mol, J. P. S., Silva, A. P. C., Macêdo, A. A., Silva, T. M. A., Alves, G. E. S., Winter, S., Winter, M. G., Velazquez, E. M., Byndloss, M. X., Baumler, A. J., Tsolis, R. M., Paixão, T. A., & Santos, R. L. (2016). Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium. International Journal of Medical Microbiology, 306(8), 604-610. https://doi.org/10.1016/j.ijmm.2016.10.004