Iron absorption differs in piglets fed extrinsically and intrinsically 59Fe-labeled sow's milk

J. Gislason, B. Jones, B. Lonnerdal, L. Hambraeus

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Iron bioavailability from species-specific milk is assumed to be high for the offspring, possibly due to species-specific iron-binding proteins in the milk. To assess this bioavailability using radioisotopes, the validity of extrinsic labeling technique needs to be proven. Using the suckling piglet as an animal model, we have compared iron bioavailability from sow's milk labeled extrinsically and intrinsically. During intrinsic labeling transfer into milk of 59Fe given intramuscularly was slow and was found to be at maximum 14 h post-injection. Recovery of isotope in the milk was only 0.00014%. Extrinsic and intrinsic labels were distributed differently among milk fractions; intrinsic iron bound primarily to the fat fraction but the extrinsic iron bound primarily to the casein fraction. Iron retention from intrinsically labeled milk was considerably higher than from extrinsically labeled milk. These results show that the extrinsic tag method is not valid for studies on iron absorption from sow's milk and suggest that the situation may be the same for human milk.

Original languageEnglish (US)
Pages (from-to)1287-1292
Number of pages6
JournalJournal of Nutrition
Volume122
Issue number6
StatePublished - 1992

Fingerprint

sow milk
iron absorption
piglets
Milk
Iron
milk
iron
bioavailability
Biological Availability
labeling techniques
Iron-Binding Proteins
breast milk
radionuclides
suckling
binding proteins
casein
isotopes
Human Milk
Caseins
animal models

Keywords

  • extrinsic labeling
  • iron absorption
  • lactoferrin
  • piglets
  • sow's milk

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Gislason, J., Jones, B., Lonnerdal, B., & Hambraeus, L. (1992). Iron absorption differs in piglets fed extrinsically and intrinsically 59Fe-labeled sow's milk. Journal of Nutrition, 122(6), 1287-1292.

Iron absorption differs in piglets fed extrinsically and intrinsically 59Fe-labeled sow's milk. / Gislason, J.; Jones, B.; Lonnerdal, B.; Hambraeus, L.

In: Journal of Nutrition, Vol. 122, No. 6, 1992, p. 1287-1292.

Research output: Contribution to journalArticle

Gislason, J, Jones, B, Lonnerdal, B & Hambraeus, L 1992, 'Iron absorption differs in piglets fed extrinsically and intrinsically 59Fe-labeled sow's milk', Journal of Nutrition, vol. 122, no. 6, pp. 1287-1292.
Gislason, J. ; Jones, B. ; Lonnerdal, B. ; Hambraeus, L. / Iron absorption differs in piglets fed extrinsically and intrinsically 59Fe-labeled sow's milk. In: Journal of Nutrition. 1992 ; Vol. 122, No. 6. pp. 1287-1292.
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