Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular 'second messengers' and control excitation-contraction coupling, excitation-secretion, oxidative phosphorylation, and mitochondrial acid-base balance. The present study examines the effect of septic shock on serum (Ca2+) and (Mg2+). Five adult female baboons were subjected to live E. coli septic shock and then resuscitated. Three baboons served as controls. Ca2+ was measured by the Orion SS-20 flow-through calcium electrode and Mg2+ calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, phosphate, albumin, globulin, hematocrit, and total protein. This study shows that there are significant disturbances of Ca2+ and Mg 2+ during septic shock in the baboon. These disturbances may in part explain cellular dysfunction during shock including: decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Trauma|
|State||Published - 1978|
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