Ion channels in shear stress sensing in vascular endothelium ion channels in vascular mechanotransduction

Abdul I. Barakat, Deborah Lieu, Andrea Gojova

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Endothelial cell (EC) responsiveness to fluid-mechanical shear stress is essential for normal vascular function and may play a role in the localization of early atherosclerotic lesions. Although ECs are known to be exquisitely sensitive to flow, the precise mechanisms by which ECs sense and respond to shear stress remain incompletely understood. The activation of flow-sensitive ion channels is one of the most rapid endothelial responses to shear stress; therefore, these ion channels have been proposed as candidate flow sensors. A central role for flowsensitive ion channels in EC shear sensing is supported by recent data demonstrating that blocking these ion channels profoundly affects downstream endothelial flow signaling.

Original languageEnglish (US)
Title of host publicationMolecular Sensors for Cardiovascular Homeostasis
PublisherSpringer US
Pages155-170
Number of pages16
ISBN (Print)0387475281, 9780387475288
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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    Barakat, A. I., Lieu, D., & Gojova, A. (2007). Ion channels in shear stress sensing in vascular endothelium ion channels in vascular mechanotransduction. In Molecular Sensors for Cardiovascular Homeostasis (pp. 155-170). Springer US. https://doi.org/10.1007/978-0-387-47530-1_9