Ion channels in innate and adaptive immunity

Stefan Feske, Heike Wulff, Edward Y. Skolnik

Research output: Contribution to journalArticlepeer-review

309 Scopus citations


Ion channels and transporters mediate the transport of charged ions across hydrophobic lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc have important roles as second messengers to regulate intracellular signaling pathways. By contrast, monovalent cations such as sodium and potassium mainly regulate the membrane potential, which indirectly controls the influx of calcium and immune cell signaling. Studies investigating human patients with mutations in ion channels and transporters, analysis of gene-targeted mice, or pharmacological experiments with ion channel inhibitors have revealed important roles of ionic signals in lymphocyte development and in innate and adaptive immune responses. We here review the mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells and discuss their roles in lymphocyte development, adaptive and innate immune responses, and autoimmunity, as well as recent efforts to develop pharmacological inhibitors of ion channels for immunomodulatory therapy.

Original languageEnglish (US)
Pages (from-to)291-353
Number of pages63
JournalAnnual Review of Immunology
StatePublished - Mar 21 2015


  • B cells
  • Calcium
  • Chloride
  • CRAC
  • DC
  • Disease
  • Ion channels
  • KCa3.1
  • KV1.3
  • Macrophages
  • Magnesium
  • Mast cells
  • ORAI
  • Potassium
  • Sodium
  • STIM
  • T cells
  • Therapy
  • Transporters
  • TRP
  • Zinc

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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