Ion Channel Localization in Axons

M. N. Rasband, James Trimmer

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Axonal voltage-gated ion channels mediate diverse electrical events, the most fundamental being the propagation of anterograde action potentials from the soma to the presynaptic terminal. This and other axonal electrical events depend on the appropriate expression, localization, and function of a repertoire of axonal ion channels that together allow for efficient transmission of electrical signals. This article discusses the ion channels found on axons and the complex molecular interactions that generate and maintain their densities and activities at precise sites in axons. Disruption of ion channel localization by disease, injury, or genetic defect leads to conduction failures and neuropathological symptoms that, depending on the type of neuron affected, can include pain, blindness, ataxia, or epilepsy.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages229-235
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rasband, M. N., & Trimmer, J. (2010). Ion Channel Localization in Axons. In Encyclopedia of Neuroscience (pp. 229-235). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01641-7