Ion and water transport across the blood-brain barrier

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

This chapter presents an overview of blood-brain barrier (BBB) structure and function with an emphasis on Cl2 transporters and channels and their role in health and disease. The blood-brain barrier comprises brain microvessel endothelial cells. It is a highly specialized endothelium that provides an important anatomic and functional barrier between the blood and the brain. The BBB has unique features that set it apart from endothelial cells of other vascular beds. This includes the presence of complex tight junctions that create a barrier with very limited paracellular solute flux and a high electrical resistance between blood and brain on the order of 2000 ohm · cm2, making this barrier comparable to tight epithelia such as those found in the distal kidney and colon. The vast majority of solutes must move across the BBB via a transendothelial rather than a paracellular route and thus it is BBB transporters that determine what moves between blood and brain.

Original languageEnglish (US)
Title of host publicationPhysiology and Pathology of chloride transporters and channels in the nervous system
PublisherElsevier Inc.
Pages585-606
Number of pages22
ISBN (Print)9780123743732
DOIs
StatePublished - 2010

Fingerprint

Ion Transport
Blood-Brain Barrier
Ions
Brain
Water
Blood
Endothelial cells
Endothelial Cells
Acoustic impedance
Tight Junctions
Microvessels
Electric Impedance
Endothelium
Health
Fluxes
Colon
Epithelium
Kidney

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

O'Donnell, M. E. (2010). Ion and water transport across the blood-brain barrier. In Physiology and Pathology of chloride transporters and channels in the nervous system (pp. 585-606). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374373-2.00030-3

Ion and water transport across the blood-brain barrier. / O'Donnell, Martha E.

Physiology and Pathology of chloride transporters and channels in the nervous system. Elsevier Inc., 2010. p. 585-606.

Research output: Chapter in Book/Report/Conference proceedingChapter

O'Donnell, ME 2010, Ion and water transport across the blood-brain barrier. in Physiology and Pathology of chloride transporters and channels in the nervous system. Elsevier Inc., pp. 585-606. https://doi.org/10.1016/B978-0-12-374373-2.00030-3
O'Donnell ME. Ion and water transport across the blood-brain barrier. In Physiology and Pathology of chloride transporters and channels in the nervous system. Elsevier Inc. 2010. p. 585-606 https://doi.org/10.1016/B978-0-12-374373-2.00030-3
O'Donnell, Martha E. / Ion and water transport across the blood-brain barrier. Physiology and Pathology of chloride transporters and channels in the nervous system. Elsevier Inc., 2010. pp. 585-606
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