Abstract
This chapter presents an overview of blood-brain barrier (BBB) structure and function with an emphasis on Cl2 transporters and channels and their role in health and disease. The blood-brain barrier comprises brain microvessel endothelial cells. It is a highly specialized endothelium that provides an important anatomic and functional barrier between the blood and the brain. The BBB has unique features that set it apart from endothelial cells of other vascular beds. This includes the presence of complex tight junctions that create a barrier with very limited paracellular solute flux and a high electrical resistance between blood and brain on the order of 2000 ohm · cm2, making this barrier comparable to tight epithelia such as those found in the distal kidney and colon. The vast majority of solutes must move across the BBB via a transendothelial rather than a paracellular route and thus it is BBB transporters that determine what moves between blood and brain.
| Original language | English (US) |
|---|---|
| Title of host publication | Physiology and Pathology of chloride transporters and channels in the nervous system |
| Publisher | Elsevier Inc. |
| Pages | 585-606 |
| Number of pages | 22 |
| ISBN (Print) | 9780123743732 |
| DOIs | |
| State | Published - 2010 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Ion and water transport across the blood-brain barrier. / O'Donnell, Martha E.
Physiology and Pathology of chloride transporters and channels in the nervous system. Elsevier Inc., 2010. p. 585-606.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Ion and water transport across the blood-brain barrier
AU - O'Donnell, Martha E
PY - 2010
Y1 - 2010
N2 - This chapter presents an overview of blood-brain barrier (BBB) structure and function with an emphasis on Cl2 transporters and channels and their role in health and disease. The blood-brain barrier comprises brain microvessel endothelial cells. It is a highly specialized endothelium that provides an important anatomic and functional barrier between the blood and the brain. The BBB has unique features that set it apart from endothelial cells of other vascular beds. This includes the presence of complex tight junctions that create a barrier with very limited paracellular solute flux and a high electrical resistance between blood and brain on the order of 2000 ohm · cm2, making this barrier comparable to tight epithelia such as those found in the distal kidney and colon. The vast majority of solutes must move across the BBB via a transendothelial rather than a paracellular route and thus it is BBB transporters that determine what moves between blood and brain.
AB - This chapter presents an overview of blood-brain barrier (BBB) structure and function with an emphasis on Cl2 transporters and channels and their role in health and disease. The blood-brain barrier comprises brain microvessel endothelial cells. It is a highly specialized endothelium that provides an important anatomic and functional barrier between the blood and the brain. The BBB has unique features that set it apart from endothelial cells of other vascular beds. This includes the presence of complex tight junctions that create a barrier with very limited paracellular solute flux and a high electrical resistance between blood and brain on the order of 2000 ohm · cm2, making this barrier comparable to tight epithelia such as those found in the distal kidney and colon. The vast majority of solutes must move across the BBB via a transendothelial rather than a paracellular route and thus it is BBB transporters that determine what moves between blood and brain.
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UR - http://www.scopus.com/inward/citedby.url?scp=84882547329&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-374373-2.00030-3
DO - 10.1016/B978-0-12-374373-2.00030-3
M3 - Chapter
AN - SCOPUS:84882547329
SN - 9780123743732
SP - 585
EP - 606
BT - Physiology and Pathology of chloride transporters and channels in the nervous system
PB - Elsevier Inc.
ER -