Jodeinbringungsgeschwindigkeit verschieden konzentrierter röntgenkontrastmittel bei schneller intravenöser injektion

Translated title of the contribution: Iodine delivery rate of different concentrations of iodine-containing contrast agents with rapid injection

Friedrich D Knollmann, K. Schimpf, R. Felix

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: To determine how the concentration of iodinated contrast media for computed tomography studies affects the iodine delivery rate at various conditions. Materials and Methods: Three nonionic, iodinated contrast agents that are marketed for computed tomography applications were administered through 1.1 and 1.3 mm large peripheral vein catheters into a vein phantom with room temperature and with pre-heating of the agents at 37 °C using a power injector. Each injection applied 40 ml of contrast medium at a flow rate of four to eight ml/s. The iodine concentration of lopromide, lomeprol, and lodixanol varied between 300 and 400 mg iodine per cc. The power injector used a pressure limit of 21 bar. For each experiment, the maximum iodine deliver rate was calculated from the highest possible flow rate recorded. Results: Larger vein catheters and the higher contrast temperature yielded the highest flow rates. With the higher iodine concentrations, viscosity limited the injection speed of the achievable pressure limit. The highest iodine delivery rate was 2560 mg/s, using an agent with 320 mg/ml iodine content. With the more concentrated agent, a maximal iodine delivery rate of 2400 mg/s was achieved. Conclusion: Very high iodinated contrast agent concentrations do not increase the iodine delivery rate of rapid peripheral intravenous injections, since the high viscosity of such agents causes the injection pressure to increase more than the higher iodine concentration would compensate for. With lower injection velocities, the higher viscosity of highly concentrated contrast agents may remain without practical consequences.

Original languageGerman
Pages (from-to)880-884
Number of pages5
JournalRoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren
Volume176
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Iodine
Contrast Media
Injections
Viscosity
Veins
Pressure
Catheters
Tomography
Temperature
Intravenous Injections
Heating

Keywords

  • Computed tomography, contrast enhancement
  • Contrast media, comparative studies
  • Contrast media, effects
  • Contrast media, experimental studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

@article{01ec80bb33f042ee80e849a3cc60f302,
title = "Jodeinbringungsgeschwindigkeit verschieden konzentrierter r{\"o}ntgenkontrastmittel bei schneller intraven{\"o}ser injektion",
abstract = "Purpose: To determine how the concentration of iodinated contrast media for computed tomography studies affects the iodine delivery rate at various conditions. Materials and Methods: Three nonionic, iodinated contrast agents that are marketed for computed tomography applications were administered through 1.1 and 1.3 mm large peripheral vein catheters into a vein phantom with room temperature and with pre-heating of the agents at 37 °C using a power injector. Each injection applied 40 ml of contrast medium at a flow rate of four to eight ml/s. The iodine concentration of lopromide, lomeprol, and lodixanol varied between 300 and 400 mg iodine per cc. The power injector used a pressure limit of 21 bar. For each experiment, the maximum iodine deliver rate was calculated from the highest possible flow rate recorded. Results: Larger vein catheters and the higher contrast temperature yielded the highest flow rates. With the higher iodine concentrations, viscosity limited the injection speed of the achievable pressure limit. The highest iodine delivery rate was 2560 mg/s, using an agent with 320 mg/ml iodine content. With the more concentrated agent, a maximal iodine delivery rate of 2400 mg/s was achieved. Conclusion: Very high iodinated contrast agent concentrations do not increase the iodine delivery rate of rapid peripheral intravenous injections, since the high viscosity of such agents causes the injection pressure to increase more than the higher iodine concentration would compensate for. With lower injection velocities, the higher viscosity of highly concentrated contrast agents may remain without practical consequences.",
keywords = "Computed tomography, contrast enhancement, Contrast media, comparative studies, Contrast media, effects, Contrast media, experimental studies",
author = "Knollmann, {Friedrich D} and K. Schimpf and R. Felix",
year = "2004",
month = "6",
doi = "10.1055/s-2004-812969",
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pages = "880--884",
journal = "Aktuelle Radiologie",
issn = "1433-5972",
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T1 - Jodeinbringungsgeschwindigkeit verschieden konzentrierter röntgenkontrastmittel bei schneller intravenöser injektion

AU - Knollmann, Friedrich D

AU - Schimpf, K.

AU - Felix, R.

PY - 2004/6

Y1 - 2004/6

N2 - Purpose: To determine how the concentration of iodinated contrast media for computed tomography studies affects the iodine delivery rate at various conditions. Materials and Methods: Three nonionic, iodinated contrast agents that are marketed for computed tomography applications were administered through 1.1 and 1.3 mm large peripheral vein catheters into a vein phantom with room temperature and with pre-heating of the agents at 37 °C using a power injector. Each injection applied 40 ml of contrast medium at a flow rate of four to eight ml/s. The iodine concentration of lopromide, lomeprol, and lodixanol varied between 300 and 400 mg iodine per cc. The power injector used a pressure limit of 21 bar. For each experiment, the maximum iodine deliver rate was calculated from the highest possible flow rate recorded. Results: Larger vein catheters and the higher contrast temperature yielded the highest flow rates. With the higher iodine concentrations, viscosity limited the injection speed of the achievable pressure limit. The highest iodine delivery rate was 2560 mg/s, using an agent with 320 mg/ml iodine content. With the more concentrated agent, a maximal iodine delivery rate of 2400 mg/s was achieved. Conclusion: Very high iodinated contrast agent concentrations do not increase the iodine delivery rate of rapid peripheral intravenous injections, since the high viscosity of such agents causes the injection pressure to increase more than the higher iodine concentration would compensate for. With lower injection velocities, the higher viscosity of highly concentrated contrast agents may remain without practical consequences.

AB - Purpose: To determine how the concentration of iodinated contrast media for computed tomography studies affects the iodine delivery rate at various conditions. Materials and Methods: Three nonionic, iodinated contrast agents that are marketed for computed tomography applications were administered through 1.1 and 1.3 mm large peripheral vein catheters into a vein phantom with room temperature and with pre-heating of the agents at 37 °C using a power injector. Each injection applied 40 ml of contrast medium at a flow rate of four to eight ml/s. The iodine concentration of lopromide, lomeprol, and lodixanol varied between 300 and 400 mg iodine per cc. The power injector used a pressure limit of 21 bar. For each experiment, the maximum iodine deliver rate was calculated from the highest possible flow rate recorded. Results: Larger vein catheters and the higher contrast temperature yielded the highest flow rates. With the higher iodine concentrations, viscosity limited the injection speed of the achievable pressure limit. The highest iodine delivery rate was 2560 mg/s, using an agent with 320 mg/ml iodine content. With the more concentrated agent, a maximal iodine delivery rate of 2400 mg/s was achieved. Conclusion: Very high iodinated contrast agent concentrations do not increase the iodine delivery rate of rapid peripheral intravenous injections, since the high viscosity of such agents causes the injection pressure to increase more than the higher iodine concentration would compensate for. With lower injection velocities, the higher viscosity of highly concentrated contrast agents may remain without practical consequences.

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KW - Contrast media, comparative studies

KW - Contrast media, effects

KW - Contrast media, experimental studies

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