Iodine contrast cone beam CT imaging of breast cancer

Larry Partain, Stavros Prionas, Edward Seppi, Gary Virshup, Gerhard Roos, Robert Sutherland, John M Boone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


An iodine contrast agent, in conjunction with an X-ray cone beam CT imaging system, was used to clearly image three, biopsy verified, cancer lesions in two patients. The lesions were approximately in the 10 mm to 6 mm diameter range. Additional regions were also enhanced with approximate dimensions down to 1 mm or less in diameter. A flat panel detector, with 194 μm pixels in 2 × 2 binning mode, was used to obtain 500 projection images at 30 fps with an 80 kVp X-ray system operating at 112 mAs, for an 8-9 may dose - equivalent to two view mammography for these women. The patients were positioned prone, while the gantry rotated in the horizontal plane around the uncompressed, pendant breasts. This gantry rotated 360 degrees during the patient's 16.6 sec breath hold. A volume of 100 cc of 320 mg/ml iodine-contrast was power injected at 4 cc/sec, via catheter into the arm vein of the patient. The resulting 512 × 512 × 300 cone beam CT data set of Feldkamp reconstructed ∼(0.3 mm) 3 voxels were analyzed. An interval of voxel contrast values, characteristic of the regions with iodine contrast enhancement, were used with surface rendering to clearly identify up to a total of 13 highlighted volumes. This included the three largest lesions, that were previously biopsied and confirmed to be malignant. The other ten highlighted regions, of smaller diameters, are likely areas of increased contrast trapping unrelated to cancer angiogenesis. However the technique itself is capable of resolving lesions that small.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditionPART 2
StatePublished - 2007
EventMedical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2007Feb 22 2007


OtherMedical Imaging 2007: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Breast cancer
  • Cone beam CT
  • Functional imaging
  • Iodine contrast

ASJC Scopus subject areas

  • Engineering(all)


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