The 125I-fibrinogen uptake test has proven to be a simple and accurate procedure for the detection of forming and established thrombosis, but it has limitations. Substitution of 123I for 125I provides the opportunity to obtain images of the distribution of radiolabeled fibrinogen, and this technique (123I-fibrinogen scintigraphy) has proven to be accurate in more than 350 studies of patients with thrombophlebitis. Iodine-123-fibrinogen scintigraphy appears to overcome the limitations of the 125I-fibrinogen uptake test. Although not as simple, it is noninvasive, an excellent method for detecting iliofemoral thrombophlebitis, readily discriminates thrombophlebitis, hematoma, and inflammatory diseases.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging