Iodinated nanoparticles for indirect computed tomography lymphography of the craniocervical and thoracic lymph nodes in normal dogs.

Erik R Wisner, Richard W Katzberg, P. D. Koblik, D. K. Shelton, P. E. Fisher, Stephen M Griffey, C. Drake, P. P. Harnish, A. R. Vessey, P. J. Haley

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

RATIONALE AND OBJECTIVES: We evaluated the imaging characteristics of an interstitially or intraperitoneally delivered iodinated particulate contrast agent for computed tomography (CT) lymphography of the craniocervical and thoracic lymph nodes. METHODS: We injected 2-4 ml of 15% wt/vol iodinated nanoparticle suspension subcutaneously, submucosally, or intraperitoneally in eight normal dogs. CT and plain radiographic images were obtained prior to contrast administration and 4 hr, 24 hr, and 7 days after injection. Correlation was made to detailed postmortem assessment. RESULTS: CT images showed enhancement of regional nodes draining injection sites. Mean attenuation of opacified nodes was 313 +/- 297 (mean +/- standard deviation), 536 +/- 453, and 492 +/- 372 Hounsfield units at 4 hr, 24 hr, and 7 days postinjection, respectively. Lymph node opacification on CT images correlated well with node location found at postmortem. CONCLUSION: Craniocervical and thoracic lymph nodes can be effectively opacified from interstitial or intraperitoneal delivery of this iodinated nanoparticulate contrast agent.

Original languageEnglish (US)
Pages (from-to)377-384
Number of pages8
JournalAcademic Radiology
Volume1
Issue number4
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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