Investigation of vascular inflammation induced by ceria particles synthesized by hydrogen fueled spray flame

Jun Tae Lee, Andrea Gojova, Heejung Jung, Abdul I. Barakat, Ian M. Kennedy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diesel particulate filters (DPF) have become essential as diesel regulations have become more stringent. Ceria particles suspended in fuel have been used as a catalyst to lower the regeneration temperature of DPF for light duty vehicles. However, there have been concerns about possible adverse health effects of ceria by inhalation in the case of DPF failure. Although there have been some studies of the possible adverse health effects of ceria particles, much remains to be determined. In this study, we probed the impact of ceria particles on vascular endothelial cell inflammation. Ceria particles were synthesized using a hydrogen fueled spray flame. SMPS, XRD and BET results confirmed that 35-40 nm CeO2 particles with 3-7 nm crystalline size were synthesized. Human aortic endothelial cells (HAECs) were incubated for 4 hours with the CeO2 particles at concentrations ranging from 0.001 to 50 μg/ml. Quantitative real time PCR was used to establish mRNA levels of three inflammatory makers. At the highest particle concentration tested (50 μg/ml), incubation of HAECs with CeO2 particles produced modest (1.4- to 2-fold) mRNA up-regulation for all three inflammatory markers. Our results suggest that acute exposure to CeO2 particles may elicit a modest level of vascular endothelial cell inflammation.

Original languageEnglish (US)
Title of host publication5th US Combustion Meeting 2007
PublisherCombustion Institute
Pages731-738
Number of pages8
Volume2
ISBN (Print)9781604238112
StatePublished - 2007
Event5th US Combustion Meeting 2007 - San Diego, United States
Duration: Mar 25 2007Mar 28 2007

Other

Other5th US Combustion Meeting 2007
CountryUnited States
CitySan Diego
Period3/25/073/28/07

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Physical and Theoretical Chemistry
  • Mechanical Engineering

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  • Cite this

    Lee, J. T., Gojova, A., Jung, H., Barakat, A. I., & Kennedy, I. M. (2007). Investigation of vascular inflammation induced by ceria particles synthesized by hydrogen fueled spray flame. In 5th US Combustion Meeting 2007 (Vol. 2, pp. 731-738). Combustion Institute.