Investigation of transfusion transmission of a WA1-type babesial parasite to a premature infant in California.

Anne M. Kjemtrup, Brian Lee, Curtis L. Fritz, Cherie Evans, Michael Chervenak, Patricia A Conrad

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

BACKGROUND: A premature infant in California developed respiratory distress associated with infection with a protozoal parasite, Babesia. The infant had received two blood transfusions, one from the father and one from an anonymous donor (Donor A). This study describes the follow-up required to identify the source and species of Babesia that infected the infant. STUDY DESIGN AND METHODS: At the time of the infant's illness, whole blood from the infant, father, and mother was evaluated for Babesia infection. Similar evaluation of whole blood from Donor A was performed 2 months after the suspected donation to the infant. Samples were tested using blood smear examination, serology, PCR, and hamster inoculation. Identity of the recovered Babesia parasites was confirmed by DNA amplification by PCR, genetic sequencing of the 18S gene, and phylogenetic analysis. RESULTS: WA1-type Babesia was recovered from the infant. Neither parent was the source of infection. Serology and hamster inoculation confirmed WA1-type Babesia infection in Donor A. DNA sequences of the 18S gene from the infant and donor isolates were 100% identical. CONCLUSION: WA1-type Babesia infections may be difficult to detect among blood donors because such infections can be subclinical. This is the second WA1-type Babesia transmission via blood transfusion and the first in an infant. Physicians in the western United States should consider Babesia as a possible cause of nonspecific febrile illness after a blood transfusion.

Original languageEnglish (US)
Pages (from-to)1482-1487
Number of pages6
JournalTransfusion
Volume42
Issue number11
StatePublished - Nov 2002

Fingerprint

Babesia
Premature Infants
Parasites
Infection
Tissue Donors
Blood Transfusion
Serology
Blood Donors
Fathers
Cricetinae
Polymerase Chain Reaction
Genes
Fever
Mothers
Physicians

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Kjemtrup, A. M., Lee, B., Fritz, C. L., Evans, C., Chervenak, M., & Conrad, P. A. (2002). Investigation of transfusion transmission of a WA1-type babesial parasite to a premature infant in California. Transfusion, 42(11), 1482-1487.

Investigation of transfusion transmission of a WA1-type babesial parasite to a premature infant in California. / Kjemtrup, Anne M.; Lee, Brian; Fritz, Curtis L.; Evans, Cherie; Chervenak, Michael; Conrad, Patricia A.

In: Transfusion, Vol. 42, No. 11, 11.2002, p. 1482-1487.

Research output: Contribution to journalArticle

Kjemtrup, AM, Lee, B, Fritz, CL, Evans, C, Chervenak, M & Conrad, PA 2002, 'Investigation of transfusion transmission of a WA1-type babesial parasite to a premature infant in California.', Transfusion, vol. 42, no. 11, pp. 1482-1487.
Kjemtrup, Anne M. ; Lee, Brian ; Fritz, Curtis L. ; Evans, Cherie ; Chervenak, Michael ; Conrad, Patricia A. / Investigation of transfusion transmission of a WA1-type babesial parasite to a premature infant in California. In: Transfusion. 2002 ; Vol. 42, No. 11. pp. 1482-1487.
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