Investigation of The Usefulness of Serum Amyloid A in Characterizing Selected Disease Forms of Equine Herpesvirus-1 Infection

Nicola Pusterla, Julia Miller, Sarah Varnell, Warren Armstrong, Laura Frost, Carole Michon, Kimberly Lambert, Susanna Whitfield, Bobby Cowles

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to study the SAA response of horses with various forms of EHV-1 infection. Archived serum samples from 153 horses with various disease forms of EHV-1 infection (48 healthy non-infected horses, 48 subclinically infected horses, 40 horses with respiratory EHV-1 infection and 17 horses with neurological EHV-1 infection) were available for SAA testing. SAA values ranged from 0 to 31 µg/mL (median 0 µg/mL) in healthy horses, from 0 to 2,416 µg/mL (median 8.5 µg/mL) in subclinically infected horses, from 0 to 3,000 µg/mL (median 597 µg/mL) in horse with respiratory EHV-1 infection and from 0 to 1,640 µg/mL (median 58 µg/mL) in horse with neurological EHV-1 disease. Infected horses had significantly higher SAA values compared to healthy, non-infected horses. While SAA was elevated in the majority of horses with evidence of EHV-1 infection, a single point in time SAA test was unable to consistently support infection in horses with subclinical disease

Original languageEnglish (US)
Article number103699
JournalJournal of Equine Veterinary Science
Volume104
DOIs
StatePublished - Sep 2021

Keywords

  • disease form
  • Equine herpesvirus-1
  • horse
  • serum amyloid A
  • testing

ASJC Scopus subject areas

  • Equine

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