Investigating the functional response of human cones and rods with a combined adaptive optics SLO-OCT system

Mehdi Azimipour, Denise Valente, Kari V. Vienola, John S. Werner, Robert J. Zawadzki, Ravi S. Jonnal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


In vivo functional imaging of human photoreceptors is an emerging field, with compelling potential applications in basic science, translational research, and clinical management of ophthalmic disease. Measurement of light-evoked changes in the cone photoreceptors has been successfully demonstrated using adaptive optics (AO) coherent flood illumination (CFI), AO scanning light ophthalmoscopy (SLO), AO optical coherence tomography (OCT), and full-field OCT with digital aberration correction (DAC). While the optical and computational principles of these systems differ greatly, and while these differences manifest in the resulting measurements, we believe that the approaches are all sensitive to light-evoked swelling of the cells. We describe a combined OCT-SLO with AO designed to measure this light-evoked swelling. In addition to OCT measurement of cone responses, we report their simultaneous OCT-SLO measurement as well as OCT measurement of rod photoreceptor function, neither of which, to our knowledge, have been reported before.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XXX
EditorsFabrice Manns, Arthur Ho, Per G. Soderberg
ISBN (Electronic)9781510631991
StatePublished - 2020
Event30th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Feb 1 2020Feb 2 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


Conference30th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco


  • Adaptive optics
  • Functional imaging
  • Optical coherence tomography (OCT)
  • Optoretinogram
  • Optoretinography
  • Photoreceptors
  • Scanning light ophthalmoscope (SLO)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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