Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography

Claire Robertson, Sang Won Lee, Yeh Chan Ahn, Sari Mahon, Zhongping Chen, Matthew Brenner, Steven George

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) is a nondestructive imaging technique offering high temporal and spatial resolution, which makes it a natural choice for assessing tissue mechanical properties. We have developed methods to mechanically analyze the compliance of the rabbit trachea in vivo using tissue deformations induced by tidal breathing, offering a unique tool to assess the behavior of the airways during their normal function. Four-hundred images were acquired during tidal breathing with a custom-built endoscopic OCT system. The surface of the tissue was extracted from a set of these images via image processing algorithms, filtered with a bandpass filter set at respiration frequency to remove cardiac and probe motion, and compared to ventilatory pressure to calculate wall compliance. These algorithms were tested on elastic phantoms to establish reliability and reproducibility. The mean tracheal wall compliance (in five animals) was 1.30.310 -5 (mm Pa) -1. Unlike previous work evaluating airway mechanics, this new method is applicable in vivo, noncontact, and loads the trachea in a physiological manner. The technique may have applications in assessing airway mechanics in diseases such as asthma that are characterized by significant airway remodeling.

Original languageEnglish (US)
Article number106011
JournalJournal of Biomedical Optics
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2011

Fingerprint

Optical tomography
breathing
trachea
Mechanics
tomography
Tissue
asthma
rabbits
respiration
bandpass filters
temporal resolution
imaging techniques
image processing
animals
spatial resolution
Bandpass filters
mechanical properties
Animals
Image processing
probes

Keywords

  • airway compliance
  • in vivo
  • mechanics
  • optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography. / Robertson, Claire; Lee, Sang Won; Ahn, Yeh Chan; Mahon, Sari; Chen, Zhongping; Brenner, Matthew; George, Steven.

In: Journal of Biomedical Optics, Vol. 16, No. 10, 106011, 01.10.2011.

Research output: Contribution to journalArticle

Robertson, Claire ; Lee, Sang Won ; Ahn, Yeh Chan ; Mahon, Sari ; Chen, Zhongping ; Brenner, Matthew ; George, Steven. / Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography. In: Journal of Biomedical Optics. 2011 ; Vol. 16, No. 10.
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