Invertible amphiphilic molecular pockets made of cholic acid

Juntao Luo, Yilong Chen, X. X. Zhu

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A trimer of cholic acid was prepared via a simple isocyanate linkage. Fluorescence and UV-vis spectroscopic studies showed that the same cholane trimer can form either a hydrophobic cavity in aqueous solutions or a hydrophilic cavity in an apolar solvent using pyrene and a derivative of pyrene as probes. The dynamic inversion of the cavities was demonstrated for the first time by a simple change of the polarity of the solvent media by adjusting from an aqueous buffer to tetrahydrofuran and vice versa. The NMR study of a dimer model compound of cholic acid indicated a restricted conformation exist in the solvent mixture of chloroform and methanol.

Original languageEnglish (US)
Pages (from-to)10913-10917
Number of pages5
JournalLangmuir
Volume25
Issue number18
DOIs
StatePublished - Sep 15 2009

Fingerprint

Cholic Acid
Pyrene
pyrenes
trimers
Cholanes
cavities
acids
Acids
Isocyanates
isocyanates
Chloroform
Chlorine compounds
tetrahydrofuran
chloroform
linkages
Dimers
Methanol
Conformations
polarity
Buffers

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Invertible amphiphilic molecular pockets made of cholic acid. / Luo, Juntao; Chen, Yilong; Zhu, X. X.

In: Langmuir, Vol. 25, No. 18, 15.09.2009, p. 10913-10917.

Research output: Contribution to journalArticle

Luo, J, Chen, Y & Zhu, XX 2009, 'Invertible amphiphilic molecular pockets made of cholic acid', Langmuir, vol. 25, no. 18, pp. 10913-10917. https://doi.org/10.1021/la9013703
Luo, Juntao ; Chen, Yilong ; Zhu, X. X. / Invertible amphiphilic molecular pockets made of cholic acid. In: Langmuir. 2009 ; Vol. 25, No. 18. pp. 10913-10917.
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