Invertible amphiphilic molecular pockets made of cholic acid

Juntao Luo, Yilong Chen, X. X. Zhu

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A trimer of cholic acid was prepared via a simple isocyanate linkage. Fluorescence and UV-vis spectroscopic studies showed that the same cholane trimer can form either a hydrophobic cavity in aqueous solutions or a hydrophilic cavity in an apolar solvent using pyrene and a derivative of pyrene as probes. The dynamic inversion of the cavities was demonstrated for the first time by a simple change of the polarity of the solvent media by adjusting from an aqueous buffer to tetrahydrofuran and vice versa. The NMR study of a dimer model compound of cholic acid indicated a restricted conformation exist in the solvent mixture of chloroform and methanol.

Original languageEnglish (US)
Pages (from-to)10913-10917
Number of pages5
Issue number18
StatePublished - Sep 15 2009

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy


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