Invasive Aspergillosis: Current Strategies for Diagnosis and Management

Jose Cadena, George Richard Thompson, Thomas F. Patterson

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Aspergillosis remains a significant cause of morbidity and mortality in the immunocompromised population. The spectrum of disease is broad, ranging from severe and rapidly fatal infection to noninvasive disease. The diversity of patients and risk factors complicates diagnostic and therapeutic decision-making. Invasive procedures are often precluded by host status; noninvasive diagnostic tests vary in their sensitivity and specificity. Advancements in understanding the pathophysiology of invasive aspergillosis and host genetics in differential risk have also occurred. Future work may assist in therapeutic decision-making and patient prognosis. Voriconazole remains the preferred agent for treatment. Additional alternatives have emerged.

Original languageEnglish (US)
Pages (from-to)125-142
Number of pages18
JournalInfectious Disease Clinics of North America
Volume30
Issue number1
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Aspergilloma
  • Aspergillosis
  • Chronic cavitary aspergillosis
  • Invasive pulmonary aspergillosis
  • Resistance

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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