Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase

J. Burke, P. Hwang, L. Anderson, R. Lebo, Fredric A Gorin, R. Fletterick

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The intron/exon organization of the human gene for glycogen phosphorylase has been determined. The segments of the polypeptide chain that corresponds to the 19 exons of the gene are examined for relationships between the three-dimensional structure to the protein and gene structure. Only weak correlations are observed between domains of phosphorylase and exons. The nucleotide binding domains that are found in phosphorylase and other glycolytic enzymes are examined for relationships between exons of the genes and structures of the domains. When mapped to the three-dimensional structures, the intron/exon boundaries are shown to be widely distributed in this family of protein domains.

Original languageEnglish (US)
Pages (from-to)177-187
Number of pages11
JournalProteins: Structure, Function and Genetics
Volume2
Issue number3
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Structural Biology

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