Intrinsic and extrinsic labeling for studies of manganese absorption in humans

L. Davidsson, A. Cederblad, E. Hagebo, B. Lonnerdal, B. Sandstrom

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radioisotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9% while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0% (X̄ ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.

Original languageEnglish (US)
Pages (from-to)1517-1521
Number of pages5
JournalJournal of Nutrition
Volume118
Issue number12
StatePublished - 1988
Externally publishedYes

Fingerprint

radionuclides
Manganese
Radioisotopes
manganese
Whole-Body Counting
young adults
Isotopes
Meals
Young Adult
Chickens
isotopes
chickens
liver
Liver
methodology

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Davidsson, L., Cederblad, A., Hagebo, E., Lonnerdal, B., & Sandstrom, B. (1988). Intrinsic and extrinsic labeling for studies of manganese absorption in humans. Journal of Nutrition, 118(12), 1517-1521.

Intrinsic and extrinsic labeling for studies of manganese absorption in humans. / Davidsson, L.; Cederblad, A.; Hagebo, E.; Lonnerdal, B.; Sandstrom, B.

In: Journal of Nutrition, Vol. 118, No. 12, 1988, p. 1517-1521.

Research output: Contribution to journalArticle

Davidsson, L, Cederblad, A, Hagebo, E, Lonnerdal, B & Sandstrom, B 1988, 'Intrinsic and extrinsic labeling for studies of manganese absorption in humans', Journal of Nutrition, vol. 118, no. 12, pp. 1517-1521.
Davidsson L, Cederblad A, Hagebo E, Lonnerdal B, Sandstrom B. Intrinsic and extrinsic labeling for studies of manganese absorption in humans. Journal of Nutrition. 1988;118(12):1517-1521.
Davidsson, L. ; Cederblad, A. ; Hagebo, E. ; Lonnerdal, B. ; Sandstrom, B. / Intrinsic and extrinsic labeling for studies of manganese absorption in humans. In: Journal of Nutrition. 1988 ; Vol. 118, No. 12. pp. 1517-1521.
@article{9f5eaac26d984dbfb3ffdba2d1a78902,
title = "Intrinsic and extrinsic labeling for studies of manganese absorption in humans",
abstract = "A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radioisotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9{\%} while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0{\%} (X̄ ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.",
author = "L. Davidsson and A. Cederblad and E. Hagebo and B. Lonnerdal and B. Sandstrom",
year = "1988",
language = "English (US)",
volume = "118",
pages = "1517--1521",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "12",

}

TY - JOUR

T1 - Intrinsic and extrinsic labeling for studies of manganese absorption in humans

AU - Davidsson, L.

AU - Cederblad, A.

AU - Hagebo, E.

AU - Lonnerdal, B.

AU - Sandstrom, B.

PY - 1988

Y1 - 1988

N2 - A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radioisotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9% while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0% (X̄ ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.

AB - A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radioisotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9% while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0% (X̄ ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.

UR - http://www.scopus.com/inward/record.url?scp=0024232103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024232103&partnerID=8YFLogxK

M3 - Article

C2 - 3145332

AN - SCOPUS:0024232103

VL - 118

SP - 1517

EP - 1521

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 12

ER -