Abstract
A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radioisotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9% while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0% (X̄ ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.
Original language | English (US) |
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Pages (from-to) | 1517-1521 |
Number of pages | 5 |
Journal | Journal of Nutrition |
Volume | 118 |
Issue number | 12 |
State | Published - 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)