Abstract
Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.
Original language | English (US) |
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Pages (from-to) | 381-384 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - 1976 |
Externally published | Yes |
Keywords
- 6-Hydroxydopamine
- Isolation-induced mouse fighting
- Neurotransmitters and behavior
- Norepinephrine depletion
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology