Abstract
Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-384 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1976 |
| Externally published | Yes |
Keywords
- 6-Hydroxydopamine
- Isolation-induced mouse fighting
- Neurotransmitters and behavior
- Norepinephrine depletion
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
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Cite this
Crawley, J., & Contrera, J. F. (1976). Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice. Pharmacology, Biochemistry and Behavior, 4(4), 381-384. https://doi.org/10.1016/0091-3057(76)90051-4