Abstract
Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-384 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1976 |
| Externally published | Yes |
Fingerprint
Keywords
- 6-Hydroxydopamine
- Isolation-induced mouse fighting
- Neurotransmitters and behavior
- Norepinephrine depletion
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice. / Crawley, Jacqueline; Contrera, J. F.
In: Pharmacology, Biochemistry and Behavior, Vol. 4, No. 4, 1976, p. 381-384.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice
AU - Crawley, Jacqueline
AU - Contrera, J. F.
PY - 1976
Y1 - 1976
N2 - Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.
AB - Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.
KW - 6-Hydroxydopamine
KW - Isolation-induced mouse fighting
KW - Neurotransmitters and behavior
KW - Norepinephrine depletion
UR - http://www.scopus.com/inward/record.url?scp=0017072154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017072154&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(76)90051-4
DO - 10.1016/0091-3057(76)90051-4
M3 - Article
C2 - 945581
AN - SCOPUS:0017072154
VL - 4
SP - 381
EP - 384
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -