Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice

Jacqueline Crawley; J. F. Contrera

doi:10.1016/0091-3057(76)90051-4

Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice

Jacqueline Crawley, J. F. Contrera

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(76)90051-4
State	Published - 1976
Externally published	Yes

Keywords

6-Hydroxydopamine
Isolation-induced mouse fighting
Neurotransmitters and behavior
Norepinephrine depletion

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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abstract = "Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.",

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AU - Crawley, Jacqueline

AU - Contrera, J. F.

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AB - Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.

KW - 6-Hydroxydopamine

KW - Isolation-induced mouse fighting

KW - Neurotransmitters and behavior

KW - Norepinephrine depletion

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