Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice

Jacqueline Crawley, J. F. Contrera

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Male mice with high isolation-induced fighting tendencies were administered 200 μg 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number4
StatePublished - 1976
Externally publishedYes


  • 6-Hydroxydopamine
  • Isolation-induced mouse fighting
  • Neurotransmitters and behavior
  • Norepinephrine depletion

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology


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