Abstract
A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months' duration and recurrent seizures during the preceding 2 weeks. Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified. Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease. A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma. The disease progressed despite chemotherapy with prednisone, L-asparginase, and vincristine. Postmortem histopathological examinations suggested intravascular lymphoma in the central and peripheral nervous systems as well as in multiple other organ systems. This is the first description of an antemortem diagnosis and treatment of intravascular lymphoma involving the central nervous system of a dog.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 90-96 |
| Number of pages | 7 |
| Journal | Journal of the American Animal Hospital Association |
| Volume | 39 |
| Issue number | 1 |
| State | Published - Jan 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- veterinary(all)
Cite this
Intravascular lymphoma involving the central and peripheral nervous systems in a dog. / Bush, William M.; Throop, Juliene L.; McManus, Patricia M.; Kapatkin, Amy; Vite, Charles H.; Van Winkle, Tom J.
In: Journal of the American Animal Hospital Association, Vol. 39, No. 1, 01.2003, p. 90-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intravascular lymphoma involving the central and peripheral nervous systems in a dog
AU - Bush, William M.
AU - Throop, Juliene L.
AU - McManus, Patricia M.
AU - Kapatkin, Amy
AU - Vite, Charles H.
AU - Van Winkle, Tom J.
PY - 2003/1
Y1 - 2003/1
N2 - A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months' duration and recurrent seizures during the preceding 2 weeks. Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified. Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease. A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma. The disease progressed despite chemotherapy with prednisone, L-asparginase, and vincristine. Postmortem histopathological examinations suggested intravascular lymphoma in the central and peripheral nervous systems as well as in multiple other organ systems. This is the first description of an antemortem diagnosis and treatment of intravascular lymphoma involving the central nervous system of a dog.
AB - A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months' duration and recurrent seizures during the preceding 2 weeks. Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified. Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease. A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma. The disease progressed despite chemotherapy with prednisone, L-asparginase, and vincristine. Postmortem histopathological examinations suggested intravascular lymphoma in the central and peripheral nervous systems as well as in multiple other organ systems. This is the first description of an antemortem diagnosis and treatment of intravascular lymphoma involving the central nervous system of a dog.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037250729&partnerID=8YFLogxK
M3 - Article
C2 - 12549621
AN - SCOPUS:0037250729
VL - 39
SP - 90
EP - 96
JO - Journal of the American Animal Hospital Association
JF - Journal of the American Animal Hospital Association
SN - 0587-2871
IS - 1
ER -