Research output: Contribution to journalArticlepeer-review


A method for measuring pulmonary alveolar ventilation, perfusion and volume which uses only intravascular tracers is presented. It does not require measurements at, or control of, the airway. Tracer injection into a central venous catheter or, with tolerable error, into a peripheral vein coupled with arterial blood samples provides parameters related to intervening lung vasculature, tissue, air spaces and flow dynamics. Injection of albumin-bound indocyanine green reflects intravascular variables. Iodoantipyrine freely diffuses between blood and tissue and therefore provides information regarding intravascular and tissue factors combined. The inert gases xenon and krypton diffuse through blood, tissue and air spaces giving information regarding these three spaces. The use of multiple tracers can therefore delineate otherwise inaccessible parameters, particularly alveolar air volume and ventilation.

Original languageEnglish (US)
Pages (from-to)35-36
Number of pages2
Journal[No source information available]
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)


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