Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders

Jill A Hicks, Simon Platt, Georgina Stewart, Christine Senneca, Shannon Holmes, Marc Kent, Elizabeth Howerth, Jared Kaplan, Edward Kaplan

Research output: Contribution to journalArticle

Abstract

Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. All four dogs presented with generalized seizures and had mild to no neurologic deficits at the time of craniotomy. All dogs underwent craniotomy for implantation of the microcylinders into partially resected gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma {n = 3}). All dogs recovered well from the craniotomy and implantation procedure. This novel procedure appears to be feasible and tolerated in tumour-bearing dogs. A future controlled clinical study can now aim to evaluate the microcylinder implantation for long-term efficacy.

Original languageEnglish (US)
JournalVeterinary Medicine and Science
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

temozolomide
Glioma
Canidae
Dogs
therapeutics
dogs
Craniotomy
neoplasms
Brain Neoplasms
Therapeutics
drug therapy
Oligodendroglioma
Drug Therapy
Biopolymers
gadolinium
brain
Gadolinium
Glioblastoma
Neurologic Manifestations
biopolymers

Keywords

  • canine
  • chemotherapy
  • entotherapy
  • glioma
  • magnetic resonance imaging

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Intratumoral temozolomide in spontaneous canine gliomas : feasibility of a novel therapy using implanted microcylinders. / Hicks, Jill A; Platt, Simon; Stewart, Georgina; Senneca, Christine; Holmes, Shannon; Kent, Marc; Howerth, Elizabeth; Kaplan, Jared; Kaplan, Edward.

In: Veterinary Medicine and Science, 01.01.2018.

Research output: Contribution to journalArticle

Hicks, Jill A ; Platt, Simon ; Stewart, Georgina ; Senneca, Christine ; Holmes, Shannon ; Kent, Marc ; Howerth, Elizabeth ; Kaplan, Jared ; Kaplan, Edward. / Intratumoral temozolomide in spontaneous canine gliomas : feasibility of a novel therapy using implanted microcylinders. In: Veterinary Medicine and Science. 2018.
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