Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase

Jyoti Sen, Rosana Kapeller, Ruben C Fragoso, Ranjan Sen, Leonard I. Zon, Steven J. Burakoff

Research output: Contribution to journalArticle

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Abstract

Thymocytes develop into mature functional T cells in the inductive environment of the thymus where thymocyte-stromal cell interactions and cytokines provide survival and differentiation signals as cues for thymocyte maturation. Disruption of the thymic microenvironment results in attenuation of T cell maturation, suggesting that intrathymic signals are essential for differentiation and repertoire selection. We have previously shown that several inducible nuclear factors such as AP-1, NF-AT, and NF-κB are activated in response to intrathymic signals. Here we demonstrate that in thymocytes p38 mitogen-activated protein (MAP) kinase, a member of the MAP kinase family of proteins that include the extracellular-signal regulated kinases and Jun amino-terminal kinases, is highly activated in response to intrathymic signals in vivo. These studies suggest a role for p38 MAP kinase in T cell survival and differentiation.

Original languageEnglish (US)
Pages (from-to)4535-4538
Number of pages4
JournalJournal of Immunology
Volume156
Issue number12
StatePublished - Jun 15 1996
Externally publishedYes

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p38 Mitogen-Activated Protein Kinases
Thymocytes
Extracellular Signal-Regulated MAP Kinases
T-Lymphocytes
MAP Kinase Kinase 4
Transcription Factor AP-1
Stromal Cells
Mitogen-Activated Protein Kinases
Cell Communication
Thymus Gland
Cues
Cell Differentiation
Cell Survival
Cytokines
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Sen, J., Kapeller, R., Fragoso, R. C., Sen, R., Zon, L. I., & Burakoff, S. J. (1996). Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. Journal of Immunology, 156(12), 4535-4538.

Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. / Sen, Jyoti; Kapeller, Rosana; Fragoso, Ruben C; Sen, Ranjan; Zon, Leonard I.; Burakoff, Steven J.

In: Journal of Immunology, Vol. 156, No. 12, 15.06.1996, p. 4535-4538.

Research output: Contribution to journalArticle

Sen, J, Kapeller, R, Fragoso, RC, Sen, R, Zon, LI & Burakoff, SJ 1996, 'Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase', Journal of Immunology, vol. 156, no. 12, pp. 4535-4538.
Sen J, Kapeller R, Fragoso RC, Sen R, Zon LI, Burakoff SJ. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. Journal of Immunology. 1996 Jun 15;156(12):4535-4538.
Sen, Jyoti ; Kapeller, Rosana ; Fragoso, Ruben C ; Sen, Ranjan ; Zon, Leonard I. ; Burakoff, Steven J. / Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. In: Journal of Immunology. 1996 ; Vol. 156, No. 12. pp. 4535-4538.
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