Intraseptal galanin potentiates scopolamine impairment of delayed nonmatching to sample

John K. Robinson, Jacqueline Crawley

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Galanin coexists with ACh in the basal forebrain and medial septa) region. The present study investigated the interactions of the muscarinic receptor antagonist scopolamine and the neuropeptide galanin on an operant spatial delayed nonmatching to sample task (DNMTS) in rats. Scopolamine administered both intraperitoneally and microinjected into the medial septum impaired performance on DNMTS. Galanin administered alone into the medial septum did not disrupt DNMTS, but potentiated the disruptive effects of intraperitoneal administered scopolamine. These findings raise the possibility that endogenous galanin may exacerbate cognitive impairments associated with forebrain cholinergic deficits.

Original languageEnglish (US)
Pages (from-to)5119-5125
Number of pages7
JournalJournal of Neuroscience
Volume13
Issue number12
StatePublished - 1993
Externally publishedYes

Keywords

  • ACh
  • Coexistence
  • Learning
  • Medial septum
  • Memory
  • Microinjection
  • Neuropeptide
  • Retention
  • Septohippocampal pathway

ASJC Scopus subject areas

  • Neuroscience(all)

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