Abstract
Galanin coexists with ACh in the basal forebrain and medial septa) region. The present study investigated the interactions of the muscarinic receptor antagonist scopolamine and the neuropeptide galanin on an operant spatial delayed nonmatching to sample task (DNMTS) in rats. Scopolamine administered both intraperitoneally and microinjected into the medial septum impaired performance on DNMTS. Galanin administered alone into the medial septum did not disrupt DNMTS, but potentiated the disruptive effects of intraperitoneal administered scopolamine. These findings raise the possibility that endogenous galanin may exacerbate cognitive impairments associated with forebrain cholinergic deficits.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5119-5125 |
| Number of pages | 7 |
| Journal | Journal of Neuroscience |
| Volume | 13 |
| Issue number | 12 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- ACh
- Coexistence
- Learning
- Medial septum
- Memory
- Microinjection
- Neuropeptide
- Retention
- Septohippocampal pathway
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Intraseptal galanin potentiates scopolamine impairment of delayed nonmatching to sample. / Robinson, John K.; Crawley, Jacqueline.
In: Journal of Neuroscience, Vol. 13, No. 12, 1993, p. 5119-5125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraseptal galanin potentiates scopolamine impairment of delayed nonmatching to sample
AU - Robinson, John K.
AU - Crawley, Jacqueline
PY - 1993
Y1 - 1993
N2 - Galanin coexists with ACh in the basal forebrain and medial septa) region. The present study investigated the interactions of the muscarinic receptor antagonist scopolamine and the neuropeptide galanin on an operant spatial delayed nonmatching to sample task (DNMTS) in rats. Scopolamine administered both intraperitoneally and microinjected into the medial septum impaired performance on DNMTS. Galanin administered alone into the medial septum did not disrupt DNMTS, but potentiated the disruptive effects of intraperitoneal administered scopolamine. These findings raise the possibility that endogenous galanin may exacerbate cognitive impairments associated with forebrain cholinergic deficits.
AB - Galanin coexists with ACh in the basal forebrain and medial septa) region. The present study investigated the interactions of the muscarinic receptor antagonist scopolamine and the neuropeptide galanin on an operant spatial delayed nonmatching to sample task (DNMTS) in rats. Scopolamine administered both intraperitoneally and microinjected into the medial septum impaired performance on DNMTS. Galanin administered alone into the medial septum did not disrupt DNMTS, but potentiated the disruptive effects of intraperitoneal administered scopolamine. These findings raise the possibility that endogenous galanin may exacerbate cognitive impairments associated with forebrain cholinergic deficits.
KW - ACh
KW - Coexistence
KW - Learning
KW - Medial septum
KW - Memory
KW - Microinjection
KW - Neuropeptide
KW - Retention
KW - Septohippocampal pathway
UR - http://www.scopus.com/inward/record.url?scp=0027135967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027135967&partnerID=8YFLogxK
M3 - Article
C2 - 7504722
AN - SCOPUS:0027135967
VL - 13
SP - 5119
EP - 5125
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 12
ER -