Intrapulmonary deposition and retention modeling of chrysotile asbestos fibers in rats

C. P. Yu, B. Asgharian, Kent E Pinkerton

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Previous experiments have shown that the number accumulation of chrysotile asbestos fibers in the alveolar tissue of the rat lung after a prolonged exposure is highly nonuniform. This nonuniformity arises from the asymmetry of the airway path. A theoretical model is presented to simulate the deposition and clearance processes of these fibers in an asymmetric lung in order to explain the observed nonuniformity. Calculations reveal that alveolar regions with fewer airway generations or bifurcations in their path will have a higher fiber retention and a larger mean fiber length. These results compare favorably with existing experimental data.

Original languageEnglish (US)
Pages (from-to)757-763
Number of pages7
JournalJournal of Aerosol Science
Issue number6
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Atmospheric Science
  • Environmental Science(all)


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