Intraperitoneal cisplatin chemotherapy in a canine ovarian cancer with peritoneal metastasis

Kyoung Won Seo, Jong Bok Lee, Su Ji Hong, Ye In Oh, Su Hyung Lee, Hwa Young Youn, Goo Jang

Research output: Contribution to journalArticle

Abstract

A 4-year-old female Shih-tzu dog weighing 5.1 kg was referred with abdominal distension and diagnosed as cystic papillary adenocarcinoma with metastasis to serosal surface of abdomen by biopsy. Intraperitoneal chemotherapy with cisplatin (50 mg/m2) diluted in normal saline (250 ml/m2) was initiated following removal of ascites one month after ovariohysterectomy (OHE). Clinical response was great and had no side effects during the chemotherapy period (3 relapses, 33 months after diagnosis). However, pleural effusion occurred with ascites and renal failure at the end of treatment. Eleven treatments of cisplatin were performed during 35 months after diagnosis. Intraperitoneal cisplatin instillation has been effective to control malignant ascites and pleural effusion in ovarian cancers and could be a reasonable palliative treatment. This is the first case report describing intraperitoneal cisplatin chemotherapy in metastatic ovarian cyst papillary adenocarcinoma in Korea.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalJournal of Veterinary Clinics
Volume28
Issue number6
StatePublished - Dec 1 2011
Externally publishedYes

Keywords

  • Chemotherapy
  • Dog
  • Malignant ascites
  • Ovarian metastatic cancer

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Seo, K. W., Lee, J. B., Hong, S. J., Oh, Y. I., Lee, S. H., Youn, H. Y., & Jang, G. (2011). Intraperitoneal cisplatin chemotherapy in a canine ovarian cancer with peritoneal metastasis. Journal of Veterinary Clinics, 28(6), 598-602.