Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament Gene

J. C. Vickers, R. A. Lazzarini, B. M. Riederer, John Morrison

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases. To examine the possible effects of aging on the neuronal cytoskeleton containing human proteins, the retinas of transgenic mice expressing the gene for the human middle-sized neurofilament triplet were investigated at 3 or 12 months of age. Transgenic mice developed tangle-like neurofilamentous accumulations in a subset of retinal ganglion cells at 12 months of age. These neurofilamentous accumulations, which also involved endogenous neurofilament proteins, were present in the perikarya and proximal processes of large ganglion cells and were predominantly located in peripheral retina. The presence of the human protein may thus confer vulnerability of the cytoskeleton to age-related alterations in this specific retinal cell type and may serve as a model for similar cellular changes associated with Alzheimer's disease and glaucoma.

Original languageEnglish (US)
Article number71104
Pages (from-to)266-269
Number of pages4
JournalExperimental Neurology
Volume136
Issue number2
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Intermediate Filaments
Retinal Ganglion Cells
Cytoskeleton
Transgenic Mice
Genes
Retina
Neurofilament Proteins
Ganglia
Neurodegenerative Diseases
Glaucoma
Alzheimer Disease
Proteins
Neurons

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament Gene. / Vickers, J. C.; Lazzarini, R. A.; Riederer, B. M.; Morrison, John.

In: Experimental Neurology, Vol. 136, No. 2, 71104, 01.01.1995, p. 266-269.

Research output: Contribution to journalArticle

@article{d34eade3781e48bcae506ee5b88e6e26,
title = "Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament Gene",
abstract = "Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases. To examine the possible effects of aging on the neuronal cytoskeleton containing human proteins, the retinas of transgenic mice expressing the gene for the human middle-sized neurofilament triplet were investigated at 3 or 12 months of age. Transgenic mice developed tangle-like neurofilamentous accumulations in a subset of retinal ganglion cells at 12 months of age. These neurofilamentous accumulations, which also involved endogenous neurofilament proteins, were present in the perikarya and proximal processes of large ganglion cells and were predominantly located in peripheral retina. The presence of the human protein may thus confer vulnerability of the cytoskeleton to age-related alterations in this specific retinal cell type and may serve as a model for similar cellular changes associated with Alzheimer's disease and glaucoma.",
author = "Vickers, {J. C.} and Lazzarini, {R. A.} and Riederer, {B. M.} and John Morrison",
year = "1995",
month = "1",
day = "1",
doi = "10.1006/exnr.1995.1104",
language = "English (US)",
volume = "136",
pages = "266--269",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament Gene

AU - Vickers, J. C.

AU - Lazzarini, R. A.

AU - Riederer, B. M.

AU - Morrison, John

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases. To examine the possible effects of aging on the neuronal cytoskeleton containing human proteins, the retinas of transgenic mice expressing the gene for the human middle-sized neurofilament triplet were investigated at 3 or 12 months of age. Transgenic mice developed tangle-like neurofilamentous accumulations in a subset of retinal ganglion cells at 12 months of age. These neurofilamentous accumulations, which also involved endogenous neurofilament proteins, were present in the perikarya and proximal processes of large ganglion cells and were predominantly located in peripheral retina. The presence of the human protein may thus confer vulnerability of the cytoskeleton to age-related alterations in this specific retinal cell type and may serve as a model for similar cellular changes associated with Alzheimer's disease and glaucoma.

AB - Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases. To examine the possible effects of aging on the neuronal cytoskeleton containing human proteins, the retinas of transgenic mice expressing the gene for the human middle-sized neurofilament triplet were investigated at 3 or 12 months of age. Transgenic mice developed tangle-like neurofilamentous accumulations in a subset of retinal ganglion cells at 12 months of age. These neurofilamentous accumulations, which also involved endogenous neurofilament proteins, were present in the perikarya and proximal processes of large ganglion cells and were predominantly located in peripheral retina. The presence of the human protein may thus confer vulnerability of the cytoskeleton to age-related alterations in this specific retinal cell type and may serve as a model for similar cellular changes associated with Alzheimer's disease and glaucoma.

UR - http://www.scopus.com/inward/record.url?scp=0028856944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028856944&partnerID=8YFLogxK

U2 - 10.1006/exnr.1995.1104

DO - 10.1006/exnr.1995.1104

M3 - Article

C2 - 7498417

AN - SCOPUS:0028856944

VL - 136

SP - 266

EP - 269

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 2

M1 - 71104

ER -