Intraoperative Tumor Assessment Using Real-Time Molecular Imaging in Head and Neck Cancer Patients

Stan van Keulen, Naoki Nishio, Shayan Fakurnejad, Nynke S. van den Berg, Guolan Lu, Andrew Birkeland, Brock A. Martin, Tymour Forouzanfar, A. Dimitrios Colevas, Eben L. Rosenthal

Research output: Contribution to journalArticle

Abstract

Background: In head and neck cancer, surgical resection using primarily visual and tactile feedback is considered the gold standard for solid tumors. Due to high numbers of tumor-involved surgical margins, which are directly correlated to poor clinical outcomes, intraoperative optical imaging trials have rapidly proliferated over the past 5 years. However, few studies report on intraoperative in situ imaging data that could support surgical resection. To demonstrate the clinical application of in situ surgical imaging, we report on the imaging data that are directly (ie in real-time) available to the surgeon. Study Design: Fluorescence intensities and tumor-to-background ratios (TBRs) were determined from the intraoperative imaging data–the view as seen by the surgeon during tumor resection–of 20 patients, and correlated to patient and tumor characteristics including age, sex, tumor site, tumor size, histologic differentiation, and epidermal growth factor receptor (EGFR) expression. Furthermore, different lighting conditions in regard to surgical workflow were evaluated. Results: Under these circumstances, intraoperative TBRs of the primary tumors averaged 2.2 ± 0.4 (range 1.5 to 2.9). Age, sex, tumor site, and tumor size did not have a significant effect on open-field intraoperative molecular imaging of the primary tumors (p > 0.05). In addition, variation in EGFR expression levels or the presence of ambient light did not seem to alter TBRs. Conclusions: We present the results of successful in situ intraoperative imaging of primary tumors alongside the optimal conditions with respect to both molecular image acquisition and surgical workflow. This study illuminates the potentials of open-field molecular imaging to assist the surgeon in achieving successful cancer removal.

Original languageEnglish (US)
Pages (from-to)560-567.e1
JournalJournal of the American College of Surgeons
Volume229
Issue number6
DOIs
StatePublished - Dec 2019
Externally publishedYes

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Molecular Imaging
Head and Neck Neoplasms
Neoplasms
Workflow
Epidermal Growth Factor Receptor
Sensory Feedback
Optical Imaging
Touch
Lighting

ASJC Scopus subject areas

  • Surgery

Cite this

Intraoperative Tumor Assessment Using Real-Time Molecular Imaging in Head and Neck Cancer Patients. / van Keulen, Stan; Nishio, Naoki; Fakurnejad, Shayan; van den Berg, Nynke S.; Lu, Guolan; Birkeland, Andrew; Martin, Brock A.; Forouzanfar, Tymour; Colevas, A. Dimitrios; Rosenthal, Eben L.

In: Journal of the American College of Surgeons, Vol. 229, No. 6, 12.2019, p. 560-567.e1.

Research output: Contribution to journalArticle

van Keulen, S, Nishio, N, Fakurnejad, S, van den Berg, NS, Lu, G, Birkeland, A, Martin, BA, Forouzanfar, T, Colevas, AD & Rosenthal, EL 2019, 'Intraoperative Tumor Assessment Using Real-Time Molecular Imaging in Head and Neck Cancer Patients', Journal of the American College of Surgeons, vol. 229, no. 6, pp. 560-567.e1. https://doi.org/10.1016/j.jamcollsurg.2019.09.007
van Keulen, Stan ; Nishio, Naoki ; Fakurnejad, Shayan ; van den Berg, Nynke S. ; Lu, Guolan ; Birkeland, Andrew ; Martin, Brock A. ; Forouzanfar, Tymour ; Colevas, A. Dimitrios ; Rosenthal, Eben L. / Intraoperative Tumor Assessment Using Real-Time Molecular Imaging in Head and Neck Cancer Patients. In: Journal of the American College of Surgeons. 2019 ; Vol. 229, No. 6. pp. 560-567.e1.
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AU - Lu, Guolan

AU - Birkeland, Andrew

AU - Martin, Brock A.

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AU - Colevas, A. Dimitrios

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