TY - JOUR
T1 - Intraoperative retinal changes may predict surgical outcomes after epiretinal membrane peeling
AU - Mukkamala, Lekha K.
AU - Avaylon, Jaycob
AU - Welch, R. Joel
AU - Yazdanyar, Amirfarbod
AU - Emami-Naeini, Parisa
AU - Wong, Sophia
AU - Storkersen, Jordan
AU - Loo, Jessica
AU - Cunefare, David
AU - Farsiu, Sina
AU - Moshiri, Ala
AU - Park, Susanna S.
AU - Yiu, Glenn
N1 - Funding Information:
Supported by Grants from NIH R01 EY032238, NIH R21 EY031108, the BrightFocus Foundation, the Macula Society, NIH K08 EY027463, NIH P30 EY005722, Google Faculty Research Award, and the 2018 Unrestricted Grant from Research to Prevent Blindness.
Publisher Copyright:
© 2021 The Authors.
PY - 2021
Y1 - 2021
N2 - Purpose: To investigate whether intraoperative retinal changes during epiretinal membrane (ERM) peeling affect anatomic or functional outcomes after surgery. Methods: We measured retinal thickness using an intraoperative optical coherence tomography (iOCT) device in patients undergoing pars plana vitrectomy with membrane peeling for idiopathic ERM. Changes in intraoperative central macular thickness (iCMT) were compared with postoperative improvements in CMT and best-corrected visual acuity (VA). Results: Twenty-seven eyes from 27 patients (mean age 68 years) underwent iOCT-assisted ERM peeling surgery. Before surgery, mean VA was logMAR 0.50 ± 0.36 (Snellen 20/63), and mean baseline CMT was 489 ± 82 μm. Mean iCMT before peeling was 477 ± 87 μm, which correlated well with preoperative CMT (P < 0.001). Mean change in iCMT was −39.6 ± 37 μm (range −116 to +77 μm). After surgery, VA improved to logMAR 0.40 ± 0.38 (Snellen 20/50) at month 1 and logMAR 0.27 ± 0.23 (Snellen 20/37) at month 3, whereas CMT decreased to 397 ± 44 μm and 396 ± 51 μm at months 1 and 3. Eyes that underwent greater amount of iCMT change (absolute value of iCMT change) were associated with greater CMT reduction at month 1 (P < 0.001) and month 3 (P = 0.010), whereas those with greater intraoperative thinning (actual iCMT change) showed a trend toward better VA outcomes at months 1 (P = 0.054) and 3 (P = 0.036). Conclusions: Intraoperative changes in retinal thickness may predict anatomic and visual outcomes after idiopathic ERM peeling surgery. Translational Relevance: Our study suggests that intraoperative retinal tissue response to ERM peeling surgery measured by iOCT may be a prognostic indicator for restoration of retinal architecture and for visual acuity outcomes.
AB - Purpose: To investigate whether intraoperative retinal changes during epiretinal membrane (ERM) peeling affect anatomic or functional outcomes after surgery. Methods: We measured retinal thickness using an intraoperative optical coherence tomography (iOCT) device in patients undergoing pars plana vitrectomy with membrane peeling for idiopathic ERM. Changes in intraoperative central macular thickness (iCMT) were compared with postoperative improvements in CMT and best-corrected visual acuity (VA). Results: Twenty-seven eyes from 27 patients (mean age 68 years) underwent iOCT-assisted ERM peeling surgery. Before surgery, mean VA was logMAR 0.50 ± 0.36 (Snellen 20/63), and mean baseline CMT was 489 ± 82 μm. Mean iCMT before peeling was 477 ± 87 μm, which correlated well with preoperative CMT (P < 0.001). Mean change in iCMT was −39.6 ± 37 μm (range −116 to +77 μm). After surgery, VA improved to logMAR 0.40 ± 0.38 (Snellen 20/50) at month 1 and logMAR 0.27 ± 0.23 (Snellen 20/37) at month 3, whereas CMT decreased to 397 ± 44 μm and 396 ± 51 μm at months 1 and 3. Eyes that underwent greater amount of iCMT change (absolute value of iCMT change) were associated with greater CMT reduction at month 1 (P < 0.001) and month 3 (P = 0.010), whereas those with greater intraoperative thinning (actual iCMT change) showed a trend toward better VA outcomes at months 1 (P = 0.054) and 3 (P = 0.036). Conclusions: Intraoperative changes in retinal thickness may predict anatomic and visual outcomes after idiopathic ERM peeling surgery. Translational Relevance: Our study suggests that intraoperative retinal tissue response to ERM peeling surgery measured by iOCT may be a prognostic indicator for restoration of retinal architecture and for visual acuity outcomes.
KW - Epiretinal membrane
KW - Intraoperative optical coherence tomography
KW - Vision
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U2 - 10.1167/tvst.10.2.36
DO - 10.1167/tvst.10.2.36
M3 - Article
AN - SCOPUS:85102464458
VL - 10
SP - 1
EP - 10
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
SN - 2164-2591
IS - 2
M1 - 36
ER -