Intraoperative radiation therapy for high-risk pediatric neuroblastoma

Daphne A. Haas-Kogan, Benjamin M. Fisch, William M. Wara, Patrick S. Swift, Diana L Farmer, Michael R. Harrison, Craig Albanese, Vivian Weinberg, Katherine K. Matthay

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To evaluate the efficacy of intraoperative radiation therapy (IORT) in the treatment of high-risk pediatric neuroblastoma.Methods and Materials: Between 1986 and 1998, 23 children received IORT for pediatric neuroblastoma. Electron beam energies ranged from 4 MeV to 16 MeV and median dose was 10 Gy (7-16 Gy).Results: Twenty-one of 23 patients were classified as high-risk. A gross total resection (GTR) was achieved in 18 patients, of whom 6 experienced disease recurrence, 2 of which included a locoregional relapse as a component of failure. Fourteen of 18 patients receiving IORT after a GTR are disease-free survivors. A second subset of 5 patients had a subtotal resection (STR), with gross residual disease remaining after surgery. All 5 patients recurred locally, and all died of their disease. IORT was extremely well-tolerated in our cohort. Surgical resection and IORT resulted in the narrowing of the abdominal aorta and an atrophic kidney in 1 patient.Conclusions: For high-risk neuroblastoma patients, IORT as the only radiotherapy to the primary, produced excellent local control after a GTR. However, IORT as the sole radiotherapy to the primary was inadequate for patients with extensive adenopathy or an STR. In this setting, we are exploring the use of IORT as a boost in conjunction with external beam radiation therapy. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)985-992
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume47
Issue number4
DOIs
StatePublished - Jul 1 2000

Fingerprint

Neuroblastoma
radiation therapy
Radiotherapy
Pediatrics
Recurrence
aorta
Abdominal Aorta
kidneys
acceleration (physics)
surgery
set theory
Survivors
electron beams
Electrons
Kidney
dosage

Keywords

  • Intraoperative radiation
  • Neuroblastoma
  • Pediatric

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Intraoperative radiation therapy for high-risk pediatric neuroblastoma. / Haas-Kogan, Daphne A.; Fisch, Benjamin M.; Wara, William M.; Swift, Patrick S.; Farmer, Diana L; Harrison, Michael R.; Albanese, Craig; Weinberg, Vivian; Matthay, Katherine K.

In: International Journal of Radiation Oncology Biology Physics, Vol. 47, No. 4, 01.07.2000, p. 985-992.

Research output: Contribution to journalArticle

Haas-Kogan, DA, Fisch, BM, Wara, WM, Swift, PS, Farmer, DL, Harrison, MR, Albanese, C, Weinberg, V & Matthay, KK 2000, 'Intraoperative radiation therapy for high-risk pediatric neuroblastoma', International Journal of Radiation Oncology Biology Physics, vol. 47, no. 4, pp. 985-992. https://doi.org/10.1016/S0360-3016(00)00432-6
Haas-Kogan, Daphne A. ; Fisch, Benjamin M. ; Wara, William M. ; Swift, Patrick S. ; Farmer, Diana L ; Harrison, Michael R. ; Albanese, Craig ; Weinberg, Vivian ; Matthay, Katherine K. / Intraoperative radiation therapy for high-risk pediatric neuroblastoma. In: International Journal of Radiation Oncology Biology Physics. 2000 ; Vol. 47, No. 4. pp. 985-992.
@article{f2f2f6c64df94e2689c54baf2a4f540d,
title = "Intraoperative radiation therapy for high-risk pediatric neuroblastoma",
abstract = "Purpose: To evaluate the efficacy of intraoperative radiation therapy (IORT) in the treatment of high-risk pediatric neuroblastoma.Methods and Materials: Between 1986 and 1998, 23 children received IORT for pediatric neuroblastoma. Electron beam energies ranged from 4 MeV to 16 MeV and median dose was 10 Gy (7-16 Gy).Results: Twenty-one of 23 patients were classified as high-risk. A gross total resection (GTR) was achieved in 18 patients, of whom 6 experienced disease recurrence, 2 of which included a locoregional relapse as a component of failure. Fourteen of 18 patients receiving IORT after a GTR are disease-free survivors. A second subset of 5 patients had a subtotal resection (STR), with gross residual disease remaining after surgery. All 5 patients recurred locally, and all died of their disease. IORT was extremely well-tolerated in our cohort. Surgical resection and IORT resulted in the narrowing of the abdominal aorta and an atrophic kidney in 1 patient.Conclusions: For high-risk neuroblastoma patients, IORT as the only radiotherapy to the primary, produced excellent local control after a GTR. However, IORT as the sole radiotherapy to the primary was inadequate for patients with extensive adenopathy or an STR. In this setting, we are exploring the use of IORT as a boost in conjunction with external beam radiation therapy. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Intraoperative radiation, Neuroblastoma, Pediatric",
author = "Haas-Kogan, {Daphne A.} and Fisch, {Benjamin M.} and Wara, {William M.} and Swift, {Patrick S.} and Farmer, {Diana L} and Harrison, {Michael R.} and Craig Albanese and Vivian Weinberg and Matthay, {Katherine K.}",
year = "2000",
month = "7",
day = "1",
doi = "10.1016/S0360-3016(00)00432-6",
language = "English (US)",
volume = "47",
pages = "985--992",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Intraoperative radiation therapy for high-risk pediatric neuroblastoma

AU - Haas-Kogan, Daphne A.

AU - Fisch, Benjamin M.

AU - Wara, William M.

AU - Swift, Patrick S.

AU - Farmer, Diana L

AU - Harrison, Michael R.

AU - Albanese, Craig

AU - Weinberg, Vivian

AU - Matthay, Katherine K.

PY - 2000/7/1

Y1 - 2000/7/1

N2 - Purpose: To evaluate the efficacy of intraoperative radiation therapy (IORT) in the treatment of high-risk pediatric neuroblastoma.Methods and Materials: Between 1986 and 1998, 23 children received IORT for pediatric neuroblastoma. Electron beam energies ranged from 4 MeV to 16 MeV and median dose was 10 Gy (7-16 Gy).Results: Twenty-one of 23 patients were classified as high-risk. A gross total resection (GTR) was achieved in 18 patients, of whom 6 experienced disease recurrence, 2 of which included a locoregional relapse as a component of failure. Fourteen of 18 patients receiving IORT after a GTR are disease-free survivors. A second subset of 5 patients had a subtotal resection (STR), with gross residual disease remaining after surgery. All 5 patients recurred locally, and all died of their disease. IORT was extremely well-tolerated in our cohort. Surgical resection and IORT resulted in the narrowing of the abdominal aorta and an atrophic kidney in 1 patient.Conclusions: For high-risk neuroblastoma patients, IORT as the only radiotherapy to the primary, produced excellent local control after a GTR. However, IORT as the sole radiotherapy to the primary was inadequate for patients with extensive adenopathy or an STR. In this setting, we are exploring the use of IORT as a boost in conjunction with external beam radiation therapy. Copyright (C) 2000 Elsevier Science Inc.

AB - Purpose: To evaluate the efficacy of intraoperative radiation therapy (IORT) in the treatment of high-risk pediatric neuroblastoma.Methods and Materials: Between 1986 and 1998, 23 children received IORT for pediatric neuroblastoma. Electron beam energies ranged from 4 MeV to 16 MeV and median dose was 10 Gy (7-16 Gy).Results: Twenty-one of 23 patients were classified as high-risk. A gross total resection (GTR) was achieved in 18 patients, of whom 6 experienced disease recurrence, 2 of which included a locoregional relapse as a component of failure. Fourteen of 18 patients receiving IORT after a GTR are disease-free survivors. A second subset of 5 patients had a subtotal resection (STR), with gross residual disease remaining after surgery. All 5 patients recurred locally, and all died of their disease. IORT was extremely well-tolerated in our cohort. Surgical resection and IORT resulted in the narrowing of the abdominal aorta and an atrophic kidney in 1 patient.Conclusions: For high-risk neuroblastoma patients, IORT as the only radiotherapy to the primary, produced excellent local control after a GTR. However, IORT as the sole radiotherapy to the primary was inadequate for patients with extensive adenopathy or an STR. In this setting, we are exploring the use of IORT as a boost in conjunction with external beam radiation therapy. Copyright (C) 2000 Elsevier Science Inc.

KW - Intraoperative radiation

KW - Neuroblastoma

KW - Pediatric

UR - http://www.scopus.com/inward/record.url?scp=0034237688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034237688&partnerID=8YFLogxK

U2 - 10.1016/S0360-3016(00)00432-6

DO - 10.1016/S0360-3016(00)00432-6

M3 - Article

C2 - 10863069

AN - SCOPUS:0034237688

VL - 47

SP - 985

EP - 992

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 4

ER -