Intraoperative hypernatremia and polyuric syndrome induced by dexmedetomidine

Fuhai Ji, Hong Liu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Hypernatremia and polyuria are the main symptoms of diabetes insipidus. Polyuria is characterized by a 24-h urine volume in excess of 40-50 ml/kg in adults. Dexmedetomidine, a highly selective, short-acting intravenous alpha-2 agonist, is used as a component of anesthesia, and has been suspected to induce polyuric syndrome. We report a patient who presented with severe hypernatremia and polyuria after intravenous infusion of dexmedetomidine.

Original languageEnglish (US)
Pages (from-to)599-603
Number of pages5
JournalJournal of Anesthesia
Issue number4
StatePublished - Aug 2013


  • Dexmedetomidine
  • Diabetes insipidus
  • Hypernatremia
  • Polyuric syndrome

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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