Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy

Aiste Vitkunaite, Aida Laurinaviciene, Benoit Plancoulaine, Allan Rasmusson, Richard Levenson, Michael Shribak, Arvydas Laurinavicius

Research output: Contribution to journalArticlepeer-review

Abstract

Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes has been suggested. We applied polychromatic polarization microscopy to image their spatial organization. Our study provides evidence that IBI are caused by liquid paraffin-macromolecular crystals formed during paraffin-embedding procedures within cells and potentially reflect an active transcriptional status.

Original languageEnglish (US)
Article number6275
JournalScientific reports
Volume11
Issue number1
DOIs
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • General

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