Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus

M. R. Jarcho, S. P. Mendoza, W. A. Mason, X. Yang, K. L. Bales

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Arginine vasopressin (AVP) is a neuropeptide hormone and neurotransmitter that has peripheral functions in water regulation, and central functions in the stress response and social bonding in male rodents. In this study, we investigated the role of AVP in partner preference behavior in a monogamous primate, the coppery titi monkey (Callicebus cupreus). Seven titi males each received three intranasal treatments: saline, low AVP (40 IU) and high AVP (80 IU) in random order, 1 week apart. They experienced a series of stimulus exposures to their female partner, a female stranger and an empty cage. Males were more likely to contact the stimulus and do so faster when either female stimulus was present. When pretreated with saline, males contacted the stranger more frequently than their partner; when pretreated with the high dosage of AVP, males contacted their partner more frequently than the stranger. We used microarray to measure peripheral changes in gene expression associated with intranasal AVP and found reduced expression of several genes coding for proinflammatory cytokines. The data presented here suggest that intranasally administered AVP has both central influences on social behavior and peripheral influences on inflammation in a nonhuman primate.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalGenes, Brain and Behavior
Volume10
Issue number3
DOIs
StatePublished - Apr 2011

Fingerprint

Pitheciidae
Arginine Vasopressin
Vasopressins
Gene Expression
Primates
Social Behavior
Object Attachment
Neuropeptides
Haplorhini
Neurotransmitter Agents
Rodentia
Hormones
Cytokines
Inflammation

Keywords

  • Arginine vasopressin
  • Callicebus cupreus
  • Inflammation
  • Intranasal
  • Partner preference

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Genetics
  • Neurology

Cite this

Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus. / Jarcho, M. R.; Mendoza, S. P.; Mason, W. A.; Yang, X.; Bales, K. L.

In: Genes, Brain and Behavior, Vol. 10, No. 3, 04.2011, p. 375-383.

Research output: Contribution to journalArticle

Jarcho, M. R. ; Mendoza, S. P. ; Mason, W. A. ; Yang, X. ; Bales, K. L. / Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus. In: Genes, Brain and Behavior. 2011 ; Vol. 10, No. 3. pp. 375-383.
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