Intranasal histamine challenge in normality and allergic rhinitis

M. A. Birchall, I. Phillips, R. W. Fuller, N. B. Pride

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of investigations was performed in which histamine challenge was used to compare nasal responsiveness in 20 normal subjects and 20 with allergic rhinitis. There was found to be a lower threshold of reactivity (D100) to histamine in allergic subjects as measured by resistance changes (geometric mean, 0.53 mg/ml; normal subjects, 2.15: p = 0.022). This may represent increased number or sensitivity of histamine receptors on the nasal capacitance vessels. The loss of a laser Doppler response to a supramaximal histamine stimulus (normal subjects, 102% increase in flux at 3 minutes; p < 0.05) was observed in patients with allergic rhinitis and indicates either a down-regulation of the capillary system or an altered effect of histamine on superficial vessels, perhaps mediated by a shift in histamine receptor type. There was an observed increase in neutrophils at the mucosal surface under baseline conditions (rhinitis median, 49.6%; normal subjects, 32.72%: p < 0.05), which suggests an important primary role in the pathogenesis of this condition for this active cell. The observed increase in secretory volume response to histamine in allergic subjects, which persisted beyond 40 minutes after a single D100 challenge, may be related to an altered sensitivity of glandular tissue. There are important changes in nasal reactivity to histamine challenge in allergic rhinitis that may have implications for its pathogenesis.

Original languageEnglish (US)
Pages (from-to)450-456
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume109
Issue number3 I
StatePublished - 1993
Externally publishedYes

Fingerprint

Histamine
Nose
Histamine Receptors
Rhinitis
Allergic Rhinitis
Lasers
Neutrophils
Down-Regulation

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Birchall, M. A., Phillips, I., Fuller, R. W., & Pride, N. B. (1993). Intranasal histamine challenge in normality and allergic rhinitis. Otolaryngology - Head and Neck Surgery, 109(3 I), 450-456.

Intranasal histamine challenge in normality and allergic rhinitis. / Birchall, M. A.; Phillips, I.; Fuller, R. W.; Pride, N. B.

In: Otolaryngology - Head and Neck Surgery, Vol. 109, No. 3 I, 1993, p. 450-456.

Research output: Contribution to journalArticle

Birchall, MA, Phillips, I, Fuller, RW & Pride, NB 1993, 'Intranasal histamine challenge in normality and allergic rhinitis', Otolaryngology - Head and Neck Surgery, vol. 109, no. 3 I, pp. 450-456.
Birchall MA, Phillips I, Fuller RW, Pride NB. Intranasal histamine challenge in normality and allergic rhinitis. Otolaryngology - Head and Neck Surgery. 1993;109(3 I):450-456.
Birchall, M. A. ; Phillips, I. ; Fuller, R. W. ; Pride, N. B. / Intranasal histamine challenge in normality and allergic rhinitis. In: Otolaryngology - Head and Neck Surgery. 1993 ; Vol. 109, No. 3 I. pp. 450-456.
@article{c93d46a6f0524ec4b734e9cb7899fbbe,
title = "Intranasal histamine challenge in normality and allergic rhinitis",
abstract = "A series of investigations was performed in which histamine challenge was used to compare nasal responsiveness in 20 normal subjects and 20 with allergic rhinitis. There was found to be a lower threshold of reactivity (D100) to histamine in allergic subjects as measured by resistance changes (geometric mean, 0.53 mg/ml; normal subjects, 2.15: p = 0.022). This may represent increased number or sensitivity of histamine receptors on the nasal capacitance vessels. The loss of a laser Doppler response to a supramaximal histamine stimulus (normal subjects, 102{\%} increase in flux at 3 minutes; p < 0.05) was observed in patients with allergic rhinitis and indicates either a down-regulation of the capillary system or an altered effect of histamine on superficial vessels, perhaps mediated by a shift in histamine receptor type. There was an observed increase in neutrophils at the mucosal surface under baseline conditions (rhinitis median, 49.6{\%}; normal subjects, 32.72{\%}: p < 0.05), which suggests an important primary role in the pathogenesis of this condition for this active cell. The observed increase in secretory volume response to histamine in allergic subjects, which persisted beyond 40 minutes after a single D100 challenge, may be related to an altered sensitivity of glandular tissue. There are important changes in nasal reactivity to histamine challenge in allergic rhinitis that may have implications for its pathogenesis.",
author = "Birchall, {M. A.} and I. Phillips and Fuller, {R. W.} and Pride, {N. B.}",
year = "1993",
language = "English (US)",
volume = "109",
pages = "450--456",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "3 I",

}

TY - JOUR

T1 - Intranasal histamine challenge in normality and allergic rhinitis

AU - Birchall, M. A.

AU - Phillips, I.

AU - Fuller, R. W.

AU - Pride, N. B.

PY - 1993

Y1 - 1993

N2 - A series of investigations was performed in which histamine challenge was used to compare nasal responsiveness in 20 normal subjects and 20 with allergic rhinitis. There was found to be a lower threshold of reactivity (D100) to histamine in allergic subjects as measured by resistance changes (geometric mean, 0.53 mg/ml; normal subjects, 2.15: p = 0.022). This may represent increased number or sensitivity of histamine receptors on the nasal capacitance vessels. The loss of a laser Doppler response to a supramaximal histamine stimulus (normal subjects, 102% increase in flux at 3 minutes; p < 0.05) was observed in patients with allergic rhinitis and indicates either a down-regulation of the capillary system or an altered effect of histamine on superficial vessels, perhaps mediated by a shift in histamine receptor type. There was an observed increase in neutrophils at the mucosal surface under baseline conditions (rhinitis median, 49.6%; normal subjects, 32.72%: p < 0.05), which suggests an important primary role in the pathogenesis of this condition for this active cell. The observed increase in secretory volume response to histamine in allergic subjects, which persisted beyond 40 minutes after a single D100 challenge, may be related to an altered sensitivity of glandular tissue. There are important changes in nasal reactivity to histamine challenge in allergic rhinitis that may have implications for its pathogenesis.

AB - A series of investigations was performed in which histamine challenge was used to compare nasal responsiveness in 20 normal subjects and 20 with allergic rhinitis. There was found to be a lower threshold of reactivity (D100) to histamine in allergic subjects as measured by resistance changes (geometric mean, 0.53 mg/ml; normal subjects, 2.15: p = 0.022). This may represent increased number or sensitivity of histamine receptors on the nasal capacitance vessels. The loss of a laser Doppler response to a supramaximal histamine stimulus (normal subjects, 102% increase in flux at 3 minutes; p < 0.05) was observed in patients with allergic rhinitis and indicates either a down-regulation of the capillary system or an altered effect of histamine on superficial vessels, perhaps mediated by a shift in histamine receptor type. There was an observed increase in neutrophils at the mucosal surface under baseline conditions (rhinitis median, 49.6%; normal subjects, 32.72%: p < 0.05), which suggests an important primary role in the pathogenesis of this condition for this active cell. The observed increase in secretory volume response to histamine in allergic subjects, which persisted beyond 40 minutes after a single D100 challenge, may be related to an altered sensitivity of glandular tissue. There are important changes in nasal reactivity to histamine challenge in allergic rhinitis that may have implications for its pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0027381573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027381573&partnerID=8YFLogxK

M3 - Article

C2 - 8414561

AN - SCOPUS:0027381573

VL - 109

SP - 450

EP - 456

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

SN - 0194-5998

IS - 3 I

ER -