Abstract
Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.
Original language | English (US) |
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Pages (from-to) | 634-639 |
Number of pages | 6 |
Journal | Molecular Pharmacology |
Volume | 13 |
Issue number | 4 |
State | Published - 1977 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology