Abstract
Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 634-639 |
| Number of pages | 6 |
| Journal | Molecular Pharmacology |
| Volume | 13 |
| Issue number | 4 |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450. / Hjelmeland, Leonard M; Aronow, L.; Trudell, J. R.
In: Molecular Pharmacology, Vol. 13, No. 4, 1977, p. 634-639.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450
AU - Hjelmeland, Leonard M
AU - Aronow, L.
AU - Trudell, J. R.
PY - 1977
Y1 - 1977
N2 - Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.
AB - Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017654671&partnerID=8YFLogxK
M3 - Article
C2 - 887073
AN - SCOPUS:0017654671
VL - 13
SP - 634
EP - 639
JO - Molecular Pharmacology
JF - Molecular Pharmacology
SN - 0026-895X
IS - 4
ER -