Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450

Leonard M Hjelmeland; L. Aronow; J. R. Trudell

Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450

Leonard M Hjelmeland, L. Aronow, J. R. Trudell

Research output: Contribution to journal › Article › peer-review

Abstract

Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.

Original language	English (US)
Pages (from-to)	634-639
Number of pages	6
Journal	Molecular Pharmacology
Volume	13
Issue number	4
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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abstract = "Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.",

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year = "1977",

language = "English (US)",

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AU - Trudell, J. R.

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N2 - Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.

AB - Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.

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