Abstract
Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 634-639 |
| Number of pages | 6 |
| Journal | Molecular Pharmacology |
| Volume | 13 |
| Issue number | 4 |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Hjelmeland, L. M., Aronow, L., & Trudell, J. R. (1977). Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450. Molecular Pharmacology, 13(4), 634-639.