Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450

Leonard M Hjelmeland, L. Aronow, J. R. Trudell

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Abstract

Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.

Original languageEnglish (US)
Pages (from-to)634-639
Number of pages6
JournalMolecular Pharmacology
Volume13
Issue number4
StatePublished - 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

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