Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450

Leonard M Hjelmeland, L. Aronow, J. R. Trudell

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hydroxylation of monosubstituted 1,3 diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography mass fragmentography. p Methyl, p trifluoromethyl, and p fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction.

Original languageEnglish (US)
Pages (from-to)634-639
Number of pages6
JournalMolecular Pharmacology
Volume13
Issue number4
StatePublished - 1977
Externally publishedYes

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Hydroxylation
Cytochrome P-450 Enzyme System
Alcohols
Liver Microsomes
Gas Chromatography
1,3-diphenylpropane

ASJC Scopus subject areas

  • Pharmacology

Cite this

Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450. / Hjelmeland, Leonard M; Aronow, L.; Trudell, J. R.

In: Molecular Pharmacology, Vol. 13, No. 4, 1977, p. 634-639.

Research output: Contribution to journalArticle

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