Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2′,3′: 3,4]pyrrolidino[1,2-a]benzimidazoles

Liping Meng, James C. Fettinger, Mark J. Kurth

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Abstract

The parent pyrrolidino[2′,3′:3,4]pyrrolidino[1,2-a] benzimidazole heterocycle as well as a series of novel analogues have been synthesized utilizing a microwave-assisted intramolecular cycloaddition of azomethine ylides as the key transformation. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.

Original languageEnglish (US)
Pages (from-to)5055-5058
Number of pages4
JournalOrganic Letters
Volume9
Issue number24
DOIs
StatePublished - Nov 22 2007

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ASJC Scopus subject areas

  • Molecular Medicine

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