Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas N. Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, Laura Marcu

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

Original languageEnglish (US)
Article number030505
JournalJournal of Biomedical Optics
Volume14
Issue number3
DOIs
StatePublished - 2009

Keywords

  • atherosclerosis
  • fluorescence lifetime
  • fluorescence spectroscopy
  • intravascular ultrasound

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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    Stephens, D. N., Park, J., Sun, Y., Papaioannou, T., & Marcu, L. (2009). Intraluminal fluorescence spectroscopy catheter with ultrasound guidance. Journal of Biomedical Optics, 14(3), [030505]. https://doi.org/10.1117/1.3146813