Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas N. Stephens; Jesung Park; Yang Sun; Thanassis Papaioannou; Laura Marcu

doi:10.1117/1.3146813

Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas N. Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, Laura Marcu

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

Original language	English (US)
Article number	030505
Journal	Journal of Biomedical Optics
Volume	14
Issue number	3
DOIs	https://doi.org/10.1117/1.3146813
State	Published - 2009

Keywords

atherosclerosis
fluorescence lifetime
fluorescence spectroscopy
intravascular ultrasound

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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abstract = "We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.",

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AU - Park, Jesung

AU - Sun, Yang

AU - Papaioannou, Thanassis

AU - Marcu, Laura

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AB - We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

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KW - fluorescence lifetime

KW - fluorescence spectroscopy

KW - intravascular ultrasound

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Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Abstract

Keywords

ASJC Scopus subject areas

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