Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas N. Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, Laura Marcu

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

Original languageEnglish (US)
Article number030505
JournalJournal of Biomedical Optics
Issue number3
StatePublished - 2009


  • atherosclerosis
  • fluorescence lifetime
  • fluorescence spectroscopy
  • intravascular ultrasound

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics


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