Abstract
We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.
| Original language | English (US) |
|---|---|
| Article number | 030505 |
| Journal | Journal of Biomedical Optics |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2009 |
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Keywords
- atherosclerosis
- fluorescence lifetime
- fluorescence spectroscopy
- intravascular ultrasound
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Intraluminal fluorescence spectroscopy catheter with ultrasound guidance. / Stephens, Douglas N.; Park, Jesung; Sun, Yang; Papaioannou, Thanassis; Marcu, Laura.
In: Journal of Biomedical Optics, Vol. 14, No. 3, 030505, 2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraluminal fluorescence spectroscopy catheter with ultrasound guidance
AU - Stephens, Douglas N.
AU - Park, Jesung
AU - Sun, Yang
AU - Papaioannou, Thanassis
AU - Marcu, Laura
PY - 2009
Y1 - 2009
N2 - We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.
AB - We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.
KW - atherosclerosis
KW - fluorescence lifetime
KW - fluorescence spectroscopy
KW - intravascular ultrasound
UR - http://www.scopus.com/inward/record.url?scp=70349249581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349249581&partnerID=8YFLogxK
U2 - 10.1117/1.3146813
DO - 10.1117/1.3146813
M3 - Article
C2 - 19566287
AN - SCOPUS:70349249581
VL - 14
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 3
M1 - 030505
ER -