Abstract
We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.
Original language | English (US) |
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Article number | 030505 |
Journal | Journal of Biomedical Optics |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - 2009 |
Keywords
- atherosclerosis
- fluorescence lifetime
- fluorescence spectroscopy
- intravascular ultrasound
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics