Intraflagellar transport motors in cilia: Moving along the cell's antenna

Jonathan M. Scholey

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalJournal of Cell Biology
Volume180
Issue number1
DOIs
StatePublished - Jan 14 2008

ASJC Scopus subject areas

  • Cell Biology

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