Abstract
Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-29 |
| Number of pages | 7 |
| Journal | Journal of Cell Biology |
| Volume | 180 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 14 2008 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Intraflagellar transport motors in cilia : Moving along the cell's antenna. / Scholey, Jonathan M.
In: Journal of Cell Biology, Vol. 180, No. 1, 14.01.2008, p. 23-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraflagellar transport motors in cilia
T2 - Moving along the cell's antenna
AU - Scholey, Jonathan M.
PY - 2008/1/14
Y1 - 2008/1/14
N2 - Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
AB - Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
UR - http://www.scopus.com/inward/record.url?scp=38349000827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349000827&partnerID=8YFLogxK
U2 - 10.1083/jcb.200709133
DO - 10.1083/jcb.200709133
M3 - Article
C2 - 18180368
AN - SCOPUS:38349000827
VL - 180
SP - 23
EP - 29
JO - Journal of Cell Biology
JF - Journal of Cell Biology
SN - 0021-9525
IS - 1
ER -