Intraflagellar transport motors in cilia: Moving along the cell's antenna

Jonathan M. Scholey

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalJournal of Cell Biology
Volume180
Issue number1
DOIs
StatePublished - Jan 14 2008

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Cilia
Kinesin
Axoneme
Dyneins
Maintenance

ASJC Scopus subject areas

  • Cell Biology

Cite this

Intraflagellar transport motors in cilia : Moving along the cell's antenna. / Scholey, Jonathan M.

In: Journal of Cell Biology, Vol. 180, No. 1, 14.01.2008, p. 23-29.

Research output: Contribution to journalArticle

Scholey, Jonathan M. / Intraflagellar transport motors in cilia : Moving along the cell's antenna. In: Journal of Cell Biology. 2008 ; Vol. 180, No. 1. pp. 23-29.
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