Intracranial mapping of auditory perception

Event-related responses and electrocortical stimulation

A. Sinai, N. E. Crone, H. M. Wied, P. J. Franaszczuk, Diana L Miglioretti, D. Boatman-Reich

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: We compared intracranial recordings of auditory event-related responses with electrocortical stimulation mapping (ESM) to determine their functional relationship. Methods: Intracranial recordings and ESM were performed, using speech and tones, in adult epilepsy patients with subdural electrodes implanted over lateral left cortex. Evoked N1 responses and induced spectral power changes were obtained by trial averaging and time-frequency analysis. Results: ESM impaired perception and comprehension of speech, not tones, at electrode sites in the posterior temporal lobe. There was high spatial concordance between ESM sites critical for speech perception and the largest spectral power (100% concordance) and N1 (83%) responses to speech. N1 responses showed good sensitivity (0.75) and specificity (0.82), but poor positive predictive value (0.32). Conversely, increased high-frequency power (>60 Hz) showed high specificity (0.98), but poorer sensitivity (0.67) and positive predictive value (0.67). Stimulus-related differences were observed in the spatial-temporal patterns of event-related responses. Conclusions: Intracranial auditory event-related responses to speech were associated with cortical sites critical for auditory perception and comprehension of speech. Significance: These results suggest that the distribution and magnitude of intracranial auditory event-related responses to speech reflect the functional significance of the underlying cortical regions and may be useful for pre-surgical functional mapping.

Original languageEnglish (US)
Pages (from-to)140-149
Number of pages10
JournalClinical Neurophysiology
Volume120
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

Fingerprint

Auditory Perception
Speech Perception
Implanted Electrodes
Temporal Lobe
Epilepsy
Electrodes
Sensitivity and Specificity
Power (Psychology)

Keywords

  • Auditory cortex
  • Electrocortical stimulation
  • Epilepsy
  • Intracranial recording

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Intracranial mapping of auditory perception : Event-related responses and electrocortical stimulation. / Sinai, A.; Crone, N. E.; Wied, H. M.; Franaszczuk, P. J.; Miglioretti, Diana L; Boatman-Reich, D.

In: Clinical Neurophysiology, Vol. 120, No. 1, 01.2009, p. 140-149.

Research output: Contribution to journalArticle

Sinai, A. ; Crone, N. E. ; Wied, H. M. ; Franaszczuk, P. J. ; Miglioretti, Diana L ; Boatman-Reich, D. / Intracranial mapping of auditory perception : Event-related responses and electrocortical stimulation. In: Clinical Neurophysiology. 2009 ; Vol. 120, No. 1. pp. 140-149.
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