Intracranial and systemic effects of hetastarch in experimental cerebral edema

A. L. Albright, Richard E Latchaw, A. G. Robinson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

These experiments were done to determine the effectiveness of oncotic and oncotic/diuretic (oncodiuretic) therapy in dogs with experimental cerebral edema induced by a cold lesion. Dogs were divided into 3 groups and were treated for 6 h with either crystalloid (control group), a 12% hetastarch solution, or a 24% hetastarch solution plus furosemide. The cerebral effects of treatment were evaluated by intracranial pressure (ICP) measurements and by autopsy measurements of brain density and brain water content. The systemic effects were evaluated by measuring fluid balance, wedge pressure, hematocrit, free-water clearance, and serum vasopressin level. Hetastarch and hetastarch/furosemide significantly reduced ICP, increased brain density, and decreased water content of the edematous brain. Hetastarch alone caused a positive fluid balance and marked hemodilution but did not normalize vasopressin levels, whereas hetastarch/furosemide caused a marked diuresis without changing the hematocrits, and normalized vasopressin levels. Oncodiuretic therapy, in contrast to traditional fluid resection, seems to decrease ICP effectively by causing normovolemic dehydration.

Original languageEnglish (US)
Pages (from-to)496-500
Number of pages5
JournalCritical Care Medicine
Volume12
Issue number6
StatePublished - 1984
Externally publishedYes

Fingerprint

Hydroxyethyl Starch Derivatives
Brain Edema
Furosemide
Intracranial Pressure
Vasopressins
Water-Electrolyte Balance
Brain
Hematocrit
Water
Dogs
Hemodilution
Pulmonary Wedge Pressure
Diuresis
Dehydration
Diuretics
Autopsy
Therapeutics
Control Groups
Serum

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Intracranial and systemic effects of hetastarch in experimental cerebral edema. / Albright, A. L.; Latchaw, Richard E; Robinson, A. G.

In: Critical Care Medicine, Vol. 12, No. 6, 1984, p. 496-500.

Research output: Contribution to journalArticle

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