Abstract
These experiments were done to determine the effectiveness of oncotic and oncotic/diuretic (oncodiuretic) therapy in dogs with experimental cerebral edema induced by a cold lesion. Dogs were divided into 3 groups and were treated for 6 h with either crystalloid (control group), a 12% hetastarch solution, or a 24% hetastarch solution plus furosemide. The cerebral effects of treatment were evaluated by intracranial pressure (ICP) measurements and by autopsy measurements of brain density and brain water content. The systemic effects were evaluated by measuring fluid balance, wedge pressure, hematocrit, free-water clearance, and serum vasopressin level. Hetastarch and hetastarch/furosemide significantly reduced ICP, increased brain density, and decreased water content of the edematous brain. Hetastarch alone caused a positive fluid balance and marked hemodilution but did not normalize vasopressin levels, whereas hetastarch/furosemide caused a marked diuresis without changing the hematocrits, and normalized vasopressin levels. Oncodiuretic therapy, in contrast to traditional fluid resection, seems to decrease ICP effectively by causing normovolemic dehydration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 496-500 |
| Number of pages | 5 |
| Journal | Critical Care Medicine |
| Volume | 12 |
| Issue number | 6 |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Intracranial and systemic effects of hetastarch in experimental cerebral edema. / Albright, A. L.; Latchaw, Richard E; Robinson, A. G.
In: Critical Care Medicine, Vol. 12, No. 6, 1984, p. 496-500.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracranial and systemic effects of hetastarch in experimental cerebral edema
AU - Albright, A. L.
AU - Latchaw, Richard E
AU - Robinson, A. G.
PY - 1984
Y1 - 1984
N2 - These experiments were done to determine the effectiveness of oncotic and oncotic/diuretic (oncodiuretic) therapy in dogs with experimental cerebral edema induced by a cold lesion. Dogs were divided into 3 groups and were treated for 6 h with either crystalloid (control group), a 12% hetastarch solution, or a 24% hetastarch solution plus furosemide. The cerebral effects of treatment were evaluated by intracranial pressure (ICP) measurements and by autopsy measurements of brain density and brain water content. The systemic effects were evaluated by measuring fluid balance, wedge pressure, hematocrit, free-water clearance, and serum vasopressin level. Hetastarch and hetastarch/furosemide significantly reduced ICP, increased brain density, and decreased water content of the edematous brain. Hetastarch alone caused a positive fluid balance and marked hemodilution but did not normalize vasopressin levels, whereas hetastarch/furosemide caused a marked diuresis without changing the hematocrits, and normalized vasopressin levels. Oncodiuretic therapy, in contrast to traditional fluid resection, seems to decrease ICP effectively by causing normovolemic dehydration.
AB - These experiments were done to determine the effectiveness of oncotic and oncotic/diuretic (oncodiuretic) therapy in dogs with experimental cerebral edema induced by a cold lesion. Dogs were divided into 3 groups and were treated for 6 h with either crystalloid (control group), a 12% hetastarch solution, or a 24% hetastarch solution plus furosemide. The cerebral effects of treatment were evaluated by intracranial pressure (ICP) measurements and by autopsy measurements of brain density and brain water content. The systemic effects were evaluated by measuring fluid balance, wedge pressure, hematocrit, free-water clearance, and serum vasopressin level. Hetastarch and hetastarch/furosemide significantly reduced ICP, increased brain density, and decreased water content of the edematous brain. Hetastarch alone caused a positive fluid balance and marked hemodilution but did not normalize vasopressin levels, whereas hetastarch/furosemide caused a marked diuresis without changing the hematocrits, and normalized vasopressin levels. Oncodiuretic therapy, in contrast to traditional fluid resection, seems to decrease ICP effectively by causing normovolemic dehydration.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021233238&partnerID=8YFLogxK
M3 - Article
C2 - 6202463
AN - SCOPUS:0021233238
VL - 12
SP - 496
EP - 500
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 6
ER -