Intracellular study of human epileptic cortex: In vitro maintenance of epileptiform activity?

Philip A Schwartzkroin, W. Douglas Knowles

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Intracellular recordings were obtained in the in vitro slice preparation from neurons of lateral and mesial temporal cortex removed from human epileptics suffering from intractable temporal lobe seizures. Spontaneous rhythmic synoptic events, which were capable of triggering action potential discharge, were observed in many neurons, particularly in mesial tissue slices. Such activity may reflect the epileptogenic capacity of this human cortex.

Original languageEnglish (US)
Pages (from-to)709-712
Number of pages4
JournalScience
Volume223
Issue number4637
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

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