Intracellular responses of rat hippocampal granule cells in vitro to discrete applications of norepinephrine

Jean Claude Lacaille, Philip A Schwartzkroin

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

In 75% of granule cells responsive to norepinephrine (NE), micropressure application of NE near the soma of intracellularly impaled granule cells produced membrane depolarizations. Depolarizations were associated with input resistance (Rin) increases; their amplitude increased with membrane depolarization; and had an equilibrium potential of -84 mV. The β-adrenoceptor antagonist timolol blocked the depolarizations. In 38% of NE-sensitive granule cells, NE produced membrane hyperpolarizations. Hyperpolarizations were associated with decreases in Rin; increased with membrane depolarization; and reversed at > -99 mV. In some cells, in which NE was applied at different sites, both depolarizations and hyperpolarizations were observed. Both NE responses were observed in low Ca2+ high Mg2+ medium, suggesting they are due to direct postsynaptic actions of NE on granule cells.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalNeuroscience Letters
Volume89
Issue number2
DOIs
StatePublished - Jun 29 1988
Externally publishedYes

Keywords

  • Depolarization
  • Granule cell
  • Hippocampus
  • Hyperpolarization
  • Noradrenaline
  • β-Receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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